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L-Ornithine ： 交代勤務睡眠障害

C

Based on 3 studies (2 RCTs). 2/3 studies show positive effects.

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            C

        

        

            
結論

            
            
Based on 3 studies (2 RCTs). 2/3 studies show positive effects.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                1.0 weeks
                
                
                Double-blind
                
            

            
                A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the …
            
            

                
                Dose: 400 mg
                
                
                vs: Placebo
                
                
                Outcome: Circadian rhythm parameters
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: Healthy adults

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                8.0 weeks
                
                
                Double-blind
                
            

            
                Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in …
            
            

                
                Dose: 400 mg/day
                
                
                vs: placebo
                
                
                Outcome: None
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: healthy subjects

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Strategies of Functional Foods Promote Sleep in Human Being.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: Sleep quality and insomnia prevention
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: Adults with insomnia or sleep disorders

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
3

        
研究数

    

    

        
--

        
参加者数

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
グレード

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock.
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Chronobiology international
                        2018
                        
                        13 件の引用
                        
                    

                

                
                

                    

                        
                            Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers.
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Nutrition journal
                        2014
                        
                        76 件の引用
                        
                    

                

                
                

                    

                        
                            Strategies of Functional Foods Promote Sleep in Human Being.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Current signal transduction …
                        2014
                        
                        41 件の引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
sleep:

                        
400-800 mg, 30-60 min before bed

                    

                    
                

                
                

                    上限量： Not formally established; 6,000 mg/day used in exercise studies
                

                
            

            

            
            

                
研究で検討された用量

                

                    

                        
                            

                                用量
                                期間
                                効果
                                N
                            

                        
                        
                            
                            

                                400 mg
                                1.0 weeks
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                400 mg/day
                                8.0 weeks
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                推奨摂取タイミング： 30-60 minutes before bed on an empty stomach
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            GI discomfort at high doses (diarrhea)
                        
    • 
                        
                        
  • 
                            ⚠
                            Insomnia at very high doses (paradoxical in some individuals)
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            Growth hormone secretagogues — ornithine may stimulate GH release
                        
    • 
                        
                        
  • 
                            ●
                            Arginine supplements — metabolic interaction (urea cycle)
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： Not formally established; 6,000 mg/day used in exercise studies
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does L-Ornithine help with 交代勤務睡眠障害?
            
        
        

            Based on 3 studies with 0 participants, there is limited but promising evidence that L-Ornithine may support 交代勤務睡眠障害 management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much L-Ornithine should I take for 交代勤務睡眠障害?
            
        
        

            Studies have used various dosages. A commonly studied range is 400-800 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of L-Ornithine?
            
        
        

            Reported side effects may include GI discomfort at high doses (diarrhea), Insomnia at very high doses (paradoxical in some individuals). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for L-Ornithine and 交代勤務睡眠障害?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 0 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
に関する他の成分： 交代勤務睡眠障害

                    

                        
                        
                            メラトニン
                            A

                        
                        
                    

                

                

                
                

                    
L-Ornithine 他の症状・状態について

                    

                        
                        
                            不眠症
                            C

                        
                        
                    

                

                
            

        

        

    


    
    












    

        FDAに関する免責事項:
        これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。