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Kava 不安に伴う睡眠障害

A

Based on 23 studies (4 meta-analyses, 1 RCT) with 2,043 total participants. Results are mixed across studies.

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A

結論

Based on 23 studies (4 meta-analyses, 1 RCT) with 2,043 total participants. Results are mixed across studies.

Key Study Findings

Case Reports n=1 6 weeks
Diagnosing Acute Kava Dermopathy: A Case Report of a Characteristic Cutaneous Eruption.
Dose: None vs: None Outcome: acute kava dermopathy with sebaceous gland necrosis 効果: None None

対象集団: 41-year-old Australian woman consuming kava for anxiety and insomnia

Case Reports n=1 Open-label
Severe kava withdrawal managed with phenobarbital.
Dose: None vs: None Outcome: Resolution of kava withdrawal symptoms 効果: None None

対象集団: 45-year-old man with kava and kratom withdrawal

Other Double-blind
The potential of AB-free kava in enabling tobacco cessation via management of abstinence-related stress and …
Dose: AB-free kava extract vs: Placebo Outcome: Tobacco cessation via stress/insomnia management 効果: None None

対象集団: Adult smokers (trial protocol)

Controlled Clinical Trial
Acute oral toxicity, antinociceptive and antimicrobial activities of kava dried extracts and synthetic kavain.
Dose: None vs: Vehicle control Outcome: Acute oral toxicity, antinociceptive activity 効果: None None

対象集団: Animal model

Systematic Review
The Impact of Complementary and Alternative Medicine on Insomnia: A Systematic Review.
Dose: None vs: None Outcome: Sleep quality improvement 効果: None None

対象集団: Insomnia patients

Review
Calm Down With Kava: What Clinicians Need to Know.
Dose: None vs: None Outcome: None 効果: None None

対象集団: Kava users

Key Statistics

23

研究数

2043

参加者数

Mixed

A

グレード

Referenced Papers

The American journal … 2025 1 件の引用
Journal of psychosocial … 2022 2 件の引用
Combinatorial chemistry & … 2021 16 件の引用
Chemical research in … 2019 6 件の引用
Journal of medicinal … 2018 19 件の引用
Sleep medicine reviews 2015 152 件の引用
Advances in pharmacological … 2011 79 件の引用
Journal of psychopharmacology … 2005 176 件の引用
Integrative cancer therapies 2004 59 件の引用
Human psychopharmacology 2003 45 件の引用
Phytotherapy research : … 2001 74 件の引用
Der Hautarzt; Zeitschrift … 1996 22 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

sleep:
120-250 mg kavalactones/day, 1-2 hrs before bed

上限量: 250 mg kavalactones/day (European guidelines); limited to 3 months continuous use

研究で検討された用量

用量 期間 効果 N
None 6 weeks Negative 1
None -- Positive 1
AB-free kava extract -- Mixed --
None -- Positive --
None -- Mixed --
None -- Mixed --
None -- Mixed --
not specified -- Positive --

推奨摂取タイミング: 1-2 hours before bed; avoid daily use beyond 3 months without medical supervision

Safety & Side Effects

報告されている副作用

  • Drowsiness and reduced coordination
  • Hepatotoxicity (rare but serious — consult healthcare provider)
  • Skin rash (kava dermopathy) with chronic high-dose use
  • GI discomfort

既知の相互作用

  • Alcohol — increased hepatotoxicity risk and CNS depression
  • Hepatotoxic medications (acetaminophen, statins) — additive liver stress
  • Benzodiazepines and sedatives — additive CNS depression
  • CYP450 substrates (2E1, 1A2, 2D6) — kavalactones may inhibit metabolism
  • Levodopa and dopaminergic drugs — kava may reduce efficacy

耐容上限摂取量: 250 mg kavalactones/day (European guidelines); limited to 3 months continuous use

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Kava help with 不安に伴う睡眠障害?
Based on 23 studies with 2,043 participants, there is strong evidence from multiple clinical trials that Kava may support 不安に伴う睡眠障害 management. Our evidence grade is A (Strong Evidence).
How much Kava should I take for 不安に伴う睡眠障害?
Studies have used various dosages. A commonly studied range is 120-250 mg kavalactones/day, 1-2 hrs before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Kava?
Reported side effects may include Drowsiness and reduced coordination, Hepatotoxicity (rare but serious — consult healthcare provider), Skin rash (kava dermopathy) with chronic high-dose use, GI discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Kava and 不安に伴う睡眠障害?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 23 peer-reviewed studies with 2,043 total participants. The overall direction of effect is mixed.

Related Evidence

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