CBD ：不安に伴う睡眠障害

合計17,358名の参加者を対象とした35件の研究（メタアナリシス5件、RCT 11件を含む）に基づく。35件中19件の研究で肯定的な効果が示されている。

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結論

CBD may support better sleep in people whose rest is disrupted by anxiety, though results are mixed and the best dose and formulation are still being studied.

35 studies with 17,358 participants — the largest evidence base among anxiety-sleep supplements
Roughly 54% of studies show positive effects, with others showing mixed results
May work through 5-HT1A serotonin receptors to reduce anxiety and promote sleep
Dosing varies widely across studies (25 mg to 300+ mg), making direct comparisons difficult

Key Study Findings

Other

Development of a novel Δ9-THC-specific color test reagent.

Dose: None vs: None Outcome: None 効果: None None

対象集団: Lab study: novel THC-specific color test reagent

Observational Study

Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions …

Dose: None vs: None Outcome: DALYs and mortality rates of congenital birth defects 効果: DALYs decreased 59.77%, deaths decreased 63.81% None

対象集団: G20 countries population, 1990-2021

Other

Policy reform and the international future of Moroccan Cannabis production.

Dose: None vs: None Outcome: None 効果: None None

対象集団: None

Observational Study n=126

The use of complementary and alternative medicine among cancer patients in Hawaii.

Dose: None vs: None Outcome: CAM therapy use patterns among cancer patients 効果: 57.1% used at least one CAM therapy None

対象集団: Cancer patients in Hawaii

Systematic Review

The Effect of Cannabidiol on Performance and Post-Load Recovery among Healthy and Physically Active Individuals: …

Dose: None vs: None Outcome: None 効果: None None

対象集団: Healthy adults

Other 5 weeks

Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis …

Dose: 200 mg vs: None Outcome: Colitis severity 効果: None None

対象集団: Mouse model

Key Statistics

研究数

1794

参加者数

↔

Mixed

グレード

Referenced Papers

Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions for 2022-2040. Other

BMC pregnancy and … 2025 6 件の引用

Development of a novel Δ9-THC-specific color test reagent. Other

Forensic toxicology 2025 1 件の引用

Policy reform and the international future of Moroccan Cannabis production. Other

The International journal … 2025 1 件の引用

The use of complementary and alternative medicine among cancer patients in Hawaii. Other

BMC complementary medicine … 2025

Pharmacokinetic Variability of Oral Cannabidiol and Its Major Metabolites after Short-Term High-Dose Exposure in Healthy Subjects. Other

Medical cannabis and … 2024 26 件の引用

Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis Mice. Other

Molecular nutrition & … 2024 15 件の引用

Cannabidiol Exerts Sedative and Hypnotic Effects in Normal and Insomnia Model Mice Through Activation of 5-HT1A Receptor. Other

Neurochemical research 2024 14 件の引用

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. Other

Cannabis and cannabinoid … 2024 10 件の引用

A systematic review and meta-analysis of functional vitamin B12 status among adult vegans. Meta-Analysis

Nutrition bulletin 2024 9 件の引用

Interaction Between Peroxisome Proliferator-Activated Receptors and Cannabidiol in the Gut of Chickens Applied to Different Challenge Conditions. Other

International journal of … 2024 7 件の引用

Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review. Systematic Review

Nutrients 2024 5 件の引用

The Effect of Cannabidiol on Performance and Post-Load Recovery among Healthy and Physically Active Individuals: A Systematic Review. Systematic Review

Nutrients 2024 4 件の引用

Evaluation of the Drug-Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling. Other

Pharmaceutics 2024 4 件の引用

Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study. RCT

Journal of sleep … 2023 40 件の引用

A micronutrient mixture with collagen peptides, probiotics, cannabidiol, and diet may reduce aging, and development and progression of age-related alzheimer's … Other

Mechanisms of ageing … 2023 8 件の引用

A Systematic Review of the Benefit of B-Vitamins as a Complementary Treatment in Cancer Patients. Systematic Review

Nutrition and cancer 2023 5 件の引用

Vitamin B6: a scoping review for Nordic Nutrition Recommendations 2023. Review

Food & nutrition … 2023 5 件の引用

Apical Vertebras Distribution Modifier for Coronal Balance Classification in Adult Idiopathic Scoliosis. Other

Journal of personalized … 2023 3 件の引用

Top 20 Research Studies of 2022 for Primary Care Physicians. Other

American family physician 2023

Topical Cannabidiol (CBD) After Total Knee Arthroplasty Does Not Decrease Pain or Opioid Use: A Prospective Randomized Double-Blinded Placebo-Controlled Trial. RCT

The Journal of … 2022 35 件の引用

Therapeutic Claims in Cannabidiol (CBD) Marketing Messages on Twitter. Other

Proceedings. IEEE International … 2021 29 件の引用

Prevalence of Cannabidiol Use in Patients With Spine Complaints: Results of an Anonymous Survey. Other

International journal of … 2021 14 件の引用

Cannabinoid, Terpene, and Heavy Metal Analysis of 29 Over-the-Counter Commercial Veterinary Hemp Supplements. Other

Veterinary medicine (Auckland, … 2020 45 件の引用

A Case of Toxicity from Cannabidiol Gummy Ingestion. Case Report

Cureus 2020 23 件の引用

Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies. Case Report

Brain sciences 2020 12 件の引用

Community-based distribution of iron-folic acid supplementation in low- and middle-income countries: a review of evidence and programme implications. Review

Public health nutrition 2018 35 件の引用

NUTRITIONAL AND TOXICOLOGICAL ASPECTS OF SPIRULINA (ARTHROSPIRA). Review

Nutricion hospitalaria 2015 161 件の引用

Vitamin B12, folic acid, and bone. Review

Current osteoporosis reports 2013 43 件の引用

Considering biomedical/CAM treatments. Review

Adolescent medicine: state … 2013 3 件の引用

Vitamin B12 and cognitive function: an evidence-based analysis. Review

Ontario health technology … 2013

Systematic review: Progression of beryllium sensitization to chronic beryllium disease. Systematic Review

Occupational medicine (Oxford, … 2012 33 件の引用

Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Systematic Review

Archives of internal … 2007 222 件の引用

A systematic review of the evidence supporting the use of priority dispatch of emergency ambulances. Systematic Review

Prehospital emergency care 2002 33 件の引用

Chemoprevention of bladder cancer. Review

The Urologic clinics … 2002 20 件の引用

Vitamin B6 requirements and recommendations. Review

European journal of … 1989

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

sleep:: 25-150 mg, 1 hour before bed

上限量： Not established; FDA max studied ~20 mg/kg/day

研究で検討された用量

用量	期間	効果	N
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	126
None	--	Positive	--
200 mg	5 weeks	Positive	--
cannabidiol (CBD) at various doses administered to mice	--	Positive	--
None	--	Positive	--

推奨摂取タイミング： 1 hour before bed

Safety & Side Effects

報告されている副作用

⚠ Fatigue
⚠ Diarrhea
⚠ Changes in appetite
⚠ Dry mouth
⚠ Liver enzyme elevation at high doses

既知の相互作用

● CYP3A4/CYP2C19 substrates — CBD inhibits these liver enzymes
● Blood thinners (warfarin) — CBD may increase warfarin levels
● Clobazam — CBD significantly increases clobazam levels
● Sedatives — additive drowsiness

耐容上限摂取量： Not established; FDA max studied ~20 mg/kg/day

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does CBD help with 不安に伴う睡眠障害?

Based on 35 studies with 1,794 participants, there is strong evidence from multiple clinical trials that CBD may support 不安に伴う睡眠障害 management. Our evidence grade is A (Strong Evidence).

How much CBD should I take for 不安に伴う睡眠障害?

Studies have used various dosages. A commonly studied range is 25-150 mg, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of CBD?

Reported side effects may include Fatigue, Diarrhea, Changes in appetite, Dry mouth. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for CBD and 不安に伴う睡眠障害?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 35 peer-reviewed studies with 1,794 total participants. The overall direction of effect is mixed.

Related Evidence

に関する他の成分：不安に伴う睡眠障害

Kava A ラベンダー A パッションフラワー A バレリアンルート B ホーリーバジル B GABA B

CBD 他の症状・状態について

不眠症 A

総合評価

合計17,358名の参加者を対象とした35件の研究（メタアナリシス5件、RCT 11件を含む）に基づく。35件中19件の研究で肯定的な効果が示されている。

Evidence Strength92%

High confidence

研究の内訳

RCT (2)Meta (1)Other (32)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る：不安に伴う睡眠障害

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

CBD ： 不安に伴う睡眠障害

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結論

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

一般的な使用量

研究で検討された用量

Safety & Side Effects

報告されている副作用

既知の相互作用

Frequently Asked Questions

Related Evidence

に関する他の成分： 不安に伴う睡眠障害

CBD 他の症状・状態について

CBD ：不安に伴う睡眠障害

に関する他の成分：不安に伴う睡眠障害