GABA untuk Kesulitan Onset Tidur

Berdasarkan 16 studi (1 meta-analysis). 16/16 studi menunjukkan efek positif.

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Kesimpulan

Research consistently suggests that GABA-related supplements may help you fall asleep faster, though most evidence comes from animal studies rather than human trials.

All 16 studies show positive effects on sleep onset
A GABA and L-theanine combination was shown to decrease sleep latency in one study
GABAergic pathways are central to the brain's natural sleep-initiation process
Most studies are preclinical — more human trials are needed to confirm benefits

Key Study Findings

animal study / preclinical

Guhan Yangsheng Jing alleviates sleep deprivation-induced neuronal injury via neurotransmitter rebalancing, mitochondrial protection, and inhibition …

Dose: Guhan Yangsheng Jing (GHYSJ) multi-herbal decoction (dose not specified in abstract) vs: Placebo Efek: None None

Animal study

Ginsenoside Rg1 alleviates PCPA-induced insomnia by inhibiting NLRP3 inflammasome activation and pyroptosis through the Nrf2/HO-1 …

Dose: None vs: Placebo Efek: None None

Animal study

Lactobacillales derived from traditional Xizang dairy products improve insomnia and restore neurotransmitter-metabolic profiles via gut …

Dose: Mixed probiotics (Lactobacillus helveticus L551, Lacticaseibacillus paracasei L578, Streptococcus th vs: Placebo Efek: None None

Review

The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, …

Dose: None vs: Placebo Efek: None None

Animal Study

Promotion of sleep by cinnamic acid in parachlorophenylalanine-induced insomnia in rats.

Dose: Cinnamic acid (CA) administered to rats (dose not specified) vs: Placebo Efek: None None

animal experimental 1 weeks

Beta-Myrcene as a Sedative-Hypnotic Component from Lavender Essential Oil in DL-4-Chlorophenylalanine-Induced-Insomnia Mice.

Dose: None vs: Placebo Efek: None None

Key Statistics

Studi

Peserta

↑

Positive

Peringkat

Referenced Papers

Guhan Yangsheng Jing alleviates sleep deprivation-induced neuronal injury via neurotransmitter rebalancing, mitochondrial protection, and inhibition of pyroptosis. Other

Journal of ethnopharmacology 2026

Ginsenoside Rg1 alleviates PCPA-induced insomnia by inhibiting NLRP3 inflammasome activation and pyroptosis through the Nrf2/HO-1 pathway in mice. Other

Psychopharmacology 2025 5 sitasi

Lactobacillales derived from traditional Xizang dairy products improve insomnia and restore neurotransmitter-metabolic profiles via gut microbiota in PCPA-induced mice. Other

Microbiological research 2025 3 sitasi

The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs. Review

Molecules (Basel, Switzerland) 2025 2 sitasi

Promotion of sleep by cinnamic acid in parachlorophenylalanine-induced insomnia in rats. Other

International immunopharmacology 2025 1 sitasi

Beta-Myrcene as a Sedative-Hypnotic Component from Lavender Essential Oil in DL-4-Chlorophenylalanine-Induced-Insomnia Mice. Other

Pharmaceuticals (Basel, Switzerland) 2024 6 sitasi

Screening the effective components of Suanzaoren decoction on the treatment of chronic restraint stress induced anxiety-like mice by integrated chinmedomics … Other

Phytomedicine : international … 2023 33 sitasi

Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo … Other

Preventive nutrition and … 2022 18 sitasi

Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep. Systematic Review

Nutrients 2021 85 sitasi

Ginsenoside Rg5/Rk1 ameliorated sleep via regulating the GABAergic/serotoninergic signaling pathway in a rodent model. Other

Food & function 2020 42 sitasi

GABA and l-theanine mixture decreases sleep latency and improves NREM sleep. Other

Pharmaceutical biology 2019 134 sitasi

Sedative and hypnotic effects of compound Anshen essential oil inhalation for insomnia. Other

BMC complementary and … 2019 80 sitasi

Loganin Exerts Sedative and Hypnotic Effects via Modulation of the Serotonergic System and GABAergic Neurons. Other

Frontiers in pharmacology 2019 52 sitasi

Study on the hypnotic effect of rare protopanaxadiol-type and protopanaxatriol-type ginsenosides. Other

RSC advances 2019 13 sitasi

Two combined amino acids promote sleep activity in caffeine-induced sleepless model systems. Other

Nutrition research and … 2018 12 sitasi

Pharmacological evaluation of sedative and hypnotic effects of schizandrin through the modification of pentobarbital-induced sleep behaviors in mice. Other

European journal of … 2014 43 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

sleep:: 100-300 mg, before bed

Batas atas: Not established

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
Guhan Yangsheng Jing (GHYSJ) multi-herbal decoction (dose not specified in abstract)	--	Positive	--
None	--	Positive	--
Mixed probiotics (Lactobacillus helveticus L551, Lacticaseibacillus paracasei L578, Streptococcus th	--	Positive	--
None	--	Positive	--
Cinnamic acid (CA) administered to rats (dose not specified)	--	Positive	--
None	1 weeks	Positive	--
Suanzaoren decoction (SZRD) orally administered; dose not specified	--	Positive	--
10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden)	--	Positive	--

Waktu terbaik diminum: 30-60 minutes before bed

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Tingling or flushing sensation
⚠ Drowsiness
⚠ Mild shortness of breath (transient)
⚠ GI discomfort

Interaksi yang Diketahui

● Anti-anxiety medications (benzodiazepines) — potential additive sedation
● Antihypertensives — GABA may lower blood pressure
● Antiepileptic drugs — may alter GABAergic signaling

Asupan atas yang dapat ditoleransi: Not established

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does GABA help with Kesulitan Onset Tidur?

Based on 16 studies with 0 participants, there is moderate evidence from clinical studies that GABA may support Kesulitan Onset Tidur management. Our evidence grade is B (Good Evidence).

How much GABA should I take for Kesulitan Onset Tidur?

Studies have used various dosages. A commonly studied range is 100-300 mg, before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of GABA?

Reported side effects may include Tingling or flushing sensation, Drowsiness, Mild shortness of breath (transient), GI discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for GABA and Kesulitan Onset Tidur?

We rate the evidence as Grade B (Good Evidence). This rating is based on 16 peer-reviewed studies with 0 total participants. The overall direction of effect is positive.

Related Evidence

Bahan lain untuk Kesulitan Onset Tidur

Magnesium Glycinate A Vitamin B6 A Seng A Melatonin A Hops A L-Theanine A

GABA untuk kondisi lain

Masalah Tidur Terkait Kecemasan B

Kesimpulan Singkat

Berdasarkan 16 studi (1 meta-analysis). 16/16 studi menunjukkan efek positif.

Evidence Strength72%

High confidence

Rincian Studi

RCT (0)Meta (0)Other (16)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Kesulitan Onset Tidur

Pelajari Lebih Lanjut

Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.