Vitamin B6 के लिए नींद शुरू होने में कठिनाई

31 अध्ययनों (1 meta-analysis, 9 RCTs) पर आधारित, में कुल 3,623 प्रतिभागियों के साथ। 17/31 अध्ययन सकारात्मक प्रभाव दिखाते हैं।

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निष्कर्ष

Vitamin B6 may help support falling asleep faster, especially for those with low B6 levels, as it plays a key role in the body's melatonin production process.

31 studies with 3,623 participants, including 9 RCTs
About 55% of studies show positive effects on falling asleep
B6 is essential for converting tryptophan to serotonin and melatonin
May be most beneficial for people with insufficient B6 intake

Key Study Findings

Randomized Controlled Trial n=1171 26 weeks Double-blind

Antioxidant Treatment and the Chance to Conceive in Men Seeking Fertility Care: The SUMMER Randomized …

Dose: Daily: betaine 200mg, L-cystine 200mg, niacin 16mg, zinc 10mg, B6 1.4mg, B2 1.4m बनाम: Placebo Outcome: Ongoing pregnancy within 6 months प्रभाव: AOR 0.85 [0.66-1.09]; 4-6mo AOR 0.66 [0.47-0.94] 0.20 (primary); 0.02 (4-6mo wi

जनसंख्या: Men seeking fertility care (multicenter, Netherlands)

Case Reports n=3 Open-label

Underestimated pyridoxine consumption and neurotoxicity: a novel manifestation with rheumatologic relevance - a case-based review.

Dose: None बनाम: None Outcome: Neuropathy symptoms resolution upon cessation प्रभाव: None None

जनसंख्या: 3 patients with neuropathy from excess vitamin B6

In Vitro

Effects of Lactobacillus paracei JY062 Postbiotic on Intestinal Barrier, Immunity, and Gut Microbiota.

Dose: 5 mg/mL बनाम: LPS-treated cell models Outcome: Intestinal barrier function and gut microbiota प्रभाव: None None

जनसंख्या: Caco-2 cells, RAW264.7 macrophages, fecal fermentation

review

[Nutrition in improving sleep quality and fighting insomnia].

Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral बनाम: Placebo प्रभाव: None None

Mendelian randomization

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study.

Dose: None बनाम: Placebo प्रभाव: Folate vs chronotype OR 1.09 (95% CI 1.01-1.17); Vitamin B6 vs chronotype OR 0.91 (95% CI 0.86-0.96) Folate p=0.02; Vitamin B6 p=1.

Systematic Review

Preoperative Micronutrient Repletion Strategies in Metabolic and Bariatric Surgery: A Systematic Review.

Dose: Various (oral supplements, megadoses, injections) बनाम: Usual care or no treatment Outcome: Micronutrient status pre/post-surgery प्रभाव: None None

जनसंख्या: Metabolic and bariatric surgery candidates

Key Statistics

अध्ययन

126041

प्रतिभागी

↔

Mixed

ग्रेड

Referenced Papers

Effects of Lactobacillus paracei JY062 Postbiotic on Intestinal Barrier, Immunity, and Gut Microbiota. Other

Nutrients 2025 7 उद्धरण

Preoperative Micronutrient Repletion Strategies in Metabolic and Bariatric Surgery: A Systematic Review. Systematic Review

Journal of the … 2025 6 उद्धरण

Antioxidant Treatment and the Chance to Conceive in Men Seeking Fertility Care: The SUMMER Randomized Clinical Trial. RCT

JAMA network open 2025 4 उद्धरण

Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis. Meta-Analysis

Advances in nutrition … 2025 1 उद्धरण

Underestimated pyridoxine consumption and neurotoxicity: a novel manifestation with rheumatologic relevance - a case-based review. Case Report

Rheumatology international 2025 1 उद्धरण

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study. Other

Brain and behavior 2025

[Nutrition in improving sleep quality and fighting insomnia]. Review

Nutricion hospitalaria 2025

Dietary vitamin B6 supplementation alleviates heat stress-induced intestinal barrier impairment by regulating the gut microbiota and metabolites in broilers. Other

Poultry science 2024 12 उद्धरण

Effect of probiotic administration during pregnancy on the functional diversity of the gut microbiota in healthy pregnant women. RCT

Microbiology spectrum 2024 9 उद्धरण

DNA Methylation and Non-Coding RNAs in Metabolic Disorders: Epigenetic Role of Nutrients, Dietary Patterns, and Weight Loss Interventions for Precision … Review

Lifestyle genomics 2024 5 उद्धरण

Dietary intake with supplementation of vitamin D, vitamin B6, and magnesium on depressive symptoms: a public health perspective. Other

Frontiers in public … 2024 2 उद्धरण

Effects of the PREMEN-CALM® in the Management of the Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. RCT

Journal of dietary … 2024

Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. RCT

Nutrients 2023 9 उद्धरण

Complementary medicines and therapies in clinical guidelines on pregnancy care: A systematic review. Systematic Review

Women and birth … 2022 13 उद्धरण

Maternal folic acid supplement use/dietary folate intake from preconception to early pregnancy and neurodevelopment in 2-year-old offspring: the Japan Environment … Other

The British journal … 2022 7 उद्धरण

Optimizing Multivitamin Supplementation for Sleeve Gastrectomy Patients. Other

Obesity surgery 2021 13 उद्धरण

Vitamins A, B, C, and D: A Short Review for the Dermatologist. Review

Alternative therapies in … 2021 10 उद्धरण

Use of nutritional supplements based on melatonin, tryptophan and vitamin B6 (Melamil Tripto®) in children with primary chronic headache, with … RCT

Minerva pediatrica 2020 11 उद्धरण

Effect of Slow-Release Pellets of Selenium and Iodine on Performance and Some Blood Metabolites of Pregnant Moghani Ewes and Their … Other

Biological trace element … 2020 10 उद्धरण

Chemoprevention of Breast Cancer With Vitamins and Micronutrients: A Concise Review. Meta-Analysis

In vivo (Athens, … 2019 58 उद्धरण

A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Other

Complementary therapies in … 2019 26 उद्धरण

A novel approach in the management of hyperhomocysteinemia. Other

Medical hypotheses 2019 15 उद्धरण

Homocysteine and Dementia: An International Consensus Statement. Other

Journal of Alzheimer's … 2018 281 उद्धरण

Vitamin B6 blood concentrations in paediatric dialysis patients. Other

Pediatric nephrology (Berlin, … 2018 9 उद्धरण

Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. Review

The journal of … 2017 75 उद्धरण

Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing. Review

Nutrients 2016 114 उद्धरण

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? Review

Digestive diseases (Basel, … 2016 41 उद्धरण

Maternal vitamin B6 deficient or supplemented diets on expression of genes related to GABAergic, serotonergic, or glutamatergic pathways in hippocampus … Other

Molecular nutrition & … 2016 24 उद्धरण

Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence. Review

The journal of … 2015 25 उद्धरण

A prospective study of folate, vitamin B₆, and vitamin B₁₂ intake in relation to exfoliation glaucoma or suspected exfoliation glaucoma. Other

JAMA ophthalmology 2014 60 उद्धरण

Chronic idiopathic axonal polyneuropathy and vitamin B6: a controlled population-based study. Other

Journal of the … 2014 15 उद्धरण

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 उद्धरण

Pyridoxine hydrochloride treatment of carpal tunnel syndrome: a review. Review

Nutrition reviews 2004 44 उद्धरण

The immune system: a target for functional foods? Review

The British journal … 2002 358 उद्धरण

The role of vitamins in the prevention and control of anaemia. Systematic Review

Public health nutrition 2000 334 उद्धरण

Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements. Review

Seminars in thrombosis … 2000 194 उद्धरण

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

सामान्य रूप से उपयोग की जाने वाली खुराकें

sleep:: 25-50 mg with B-complex
general:: 1.3-1.7 mg/day

अधिकतम सीमा: 100 mg/day (neuropathy risk above)

अनुसंधान में अध्ययन की गई खुराकें

खुराक	अवधि	प्रभाव	N
Daily: betaine 200mg, L-cystine 200mg, niacin 16mg, zinc 10mg, B6 1.4mg, B2 1.4m	26 weeks	Negative	1171
None	--	Negative	3
5 mg/mL	--	Positive	--
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral	--	Positive	--
None	--	Mixed	--
Various (oral supplements, megadoses, injections)	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--

सेवन का सर्वोत्तम समय: Morning or with dinner; high doses before bed may increase dream vividness

Safety & Side Effects

रिपोर्ट किए गए दुष्प्रभाव

⚠ Nausea
⚠ Peripheral neuropathy at high doses (>100 mg/day)
⚠ Vivid dreams
⚠ Heartburn

ज्ञात अंतःक्रियाएँ

● Levodopa — B6 may reduce effectiveness (without carbidopa)
● Phenobarbital and phenytoin — B6 may reduce serum levels
● Cycloserine — B6 deficiency may worsen side effects

सहनीय अधिकतम सेवन: 100 mg/day (neuropathy risk above)

कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।

Frequently Asked Questions

Does Vitamin B6 help with नींद शुरू होने में कठिनाई?

Based on 36 studies with 126,041 participants, there is strong evidence from multiple clinical trials that Vitamin B6 may support नींद शुरू होने में कठिनाई management. Our evidence grade is A (Strong Evidence).

How much Vitamin B6 should I take for नींद शुरू होने में कठिनाई?

Studies have used various dosages. A commonly studied range is 25-50 mg with B-complex. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin B6?

Reported side effects may include Nausea, Peripheral neuropathy at high doses (>100 mg/day), Vivid dreams, Heartburn. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin B6 and नींद शुरू होने में कठिनाई?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 36 peer-reviewed studies with 126,041 total participants. The overall direction of effect is mixed.

Related Evidence

इसके लिए अन्य सामग्री नींद शुरू होने में कठिनाई

Magnesium Glycinate A Zinc A Melatonin A Hops A L-Theanine A Tryptophan B

Vitamin B6 अन्य स्वास्थ्य स्थितियों के लिए

अनिद्रा B

संक्षिप्त निष्कर्ष

Evidence Strength92%

High confidence

अध्ययन विश्लेषण

RCT (5)Meta (2)Other (29)

विकल्पों की तुलना करें

देखें कि इस स्वास्थ्य स्थिति के लिए अन्य सामग्री की तुलना कैसे है।

इसके लिए सभी सामग्री देखें नींद शुरू होने में कठिनाई

अधिक जानें

FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।