Caenorhabditis elegans and its applicability to studies on restless legs syndrome.

Pan Chen, Omamuyovwi Meashack Ijomone, Kun He Lee, Michael Aschner

Review Advances in pharmacology (San Diego, Calif.) 2019 5 trích dẫn

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Loại nghiên cứu: Review
Đối tượng nghiên cứu: None

Can thiệp: Caenorhabditis elegans and its applicability to studies on restless legs syndrome. None
Đối chứng: None
Kết quả chính: None
Xu hướng hiệu quả: Mixed
Nguy cơ sai lệch: Unclear

Abstract

Restless legs syndrome (RLS) is a common neurological disorder in the United States. This disorder is characterized by an irresistible urge to move the legs, although the symptoms vary in a wide range. The pathobiology of RLS has been linked to iron (Fe) deficiency and dopaminergic (DAergic) dysfunction. Several genetic factors have been reported to increase the risk of RLS. Caenorhabditis elegans (C. elegans) is a well-established animal model with a fully sequenced genome, which is highly conserved with mammals. Given the detailed knowledge of its genomic architecture, ease of genetic manipulation and conserved biosynthetic and metabolic pathways, as well as its small size, ease of maintenance, speedy generation time and large brood size, C. elegans provides numerous advantages in studying RLS-associated gene-environment interactions. Here we will review current knowledge about RLS symptoms, pathology and treatments, and discuss the application of C. elegans in RLS study, including the worm homologous genes and methods that could be performed to advance the pathophysiology RLS.

Tóm lược

Current knowledge about RLS symptoms, pathology and treatments are reviewed, and the application of C. elegans in RLS study is discussed, including the worm homologous genes and methods that could be performed to advance the pathophysiology RLS.

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Caenorhabditis elegans and its applicability to studies on restless legs syndrome.

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