Hops para Menopause-Related Sleep Disturbance

A Evidências Vários grandes ensaios clínicos mostram de forma consistente benefícios significativos.

Based on 8 studies (1 meta-analysis, 3 RCTs) with 2,688 total participants. 6/8 studies show positive effects.

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Conclusão

Based on 8 studies (1 meta-analysis, 3 RCTs) with 2,688 total participants. 6/8 studies show positive effects.

Key Study Findings

Randomized Controlled Trial n=40 3 weeks Double-blind

Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and …

Dose: None vs: Placebo Outcome: Sleep duration (Fitbit tracker) Efeito: Mean +21.7 min/night; shortest night +48.7 min 0.019

População: Adults with occasional sleep problems

Observational Study n=2464

Young adults' knowledge, perceptions and use of cannabidiol products: a mixed-methods study.

Dose: None vs: None Outcome: CBD knowledge, perceptions, and use Efeito: None None

População: US young adults, mean age 24.67y

narrative review

Use of Plant-Derived Natural Products in Sleep Disturbances.

Dose: varies by product and study vs: Placebo Efeito: None None

In Vitro

Effect of Valerian/Hop Mixture on Sleep-Related Behaviors in Drosophila melanogaster.

Dose: valerian/hops mixture (20 mg/mL valerian) vs: control diet Outcome: sleep duration and GABA receptor expression Efeito: ~20% longer sleeping time None

População: Drosophila melanogaster (fruit flies)

Systematic Review

Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient Insomnia: A Systematic Review …

Dose: None vs: placebo Outcome: None Efeito: None None

População: insomnia patients

Randomized Controlled Trial Double-blind

Treating primary insomnia - the efficacy of valerian and hops.

Dose: None vs: placebo Outcome: sleep quality Efeito: None None

População: None

Key Statistics

Estudos

2688

Participantes

↑

Positive

Nota

Referenced Papers

Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: … RCT

Brain and behavior 2025 1 citações

Young adults' knowledge, perceptions and use of cannabidiol products: a mixed-methods study. Other

Health education research 2022 14 citações

Use of Plant-Derived Natural Products in Sleep Disturbances. Review

Advances in experimental … 2021 7 citações

Effect of Valerian/Hop Mixture on Sleep-Related Behaviors in Drosophila melanogaster. Other

Biological & pharmaceutical … 2017 20 citações

Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient Insomnia: A Systematic Review of Efficacy and Safety. Other

The primary care … 2015 51 citações

Treating primary insomnia - the efficacy of valerian and hops. Review

Australian family physician 2010 58 citações

Treating the health, quality of life, and functional impairments in insomnia. Review

Journal of clinical … 2007

Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. RCT

Sleep 2005 187 citações

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

sleep:: 300-500 mg extract, 30-60 min before bed; often combined with valerian

Limite superior: Not formally established

Dosagens Estudadas em Pesquisas

Dosagem	Duração	Efeito	N
None	3 weeks	Positive	40
None	--	Neutral	2464
varies by product and study	--	Mixed	--
valerian/hops mixture (20 mg/mL valerian)	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
Valerian 187mg + hops 41.9mg extract, 2 tablets nightly	4 weeks	Positive	184

Melhor horário: 30-60 minutes before bed; commonly used with valerian root for synergistic effects

Safety & Side Effects

Efeitos Colaterais Relatados

⚠ Drowsiness (intended effect)
⚠ Mild estrogenic effects (theoretical from prenylated flavonoids)
⚠ Allergic reactions in hop-sensitive individuals

Interações Conhecidas

● Sedatives and CNS depressants — additive effects
● Estrogen-sensitive conditions — hops contain phytoestrogens
● CYP450 substrates — mild enzyme inhibition reported

Ingestão máxima tolerável: Not formally established

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Hops help with Menopause-Related Sleep Disturbance?

Based on 8 studies with 2,688 participants, there is strong evidence from multiple clinical trials that Hops may support Menopause-Related Sleep Disturbance management. Our evidence grade is A (Strong Evidence).

How much Hops should I take for Menopause-Related Sleep Disturbance?

Studies have used various dosages. A commonly studied range is 300-500 mg extract, 30-60 min before bed; often combined with valerian. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Hops?

Reported side effects may include Drowsiness (intended effect), Mild estrogenic effects (theoretical from prenylated flavonoids), Allergic reactions in hop-sensitive individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Hops and Menopause-Related Sleep Disturbance?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 8 peer-reviewed studies with 2,688 total participants. The overall direction of effect is positive.

Outros ingredientes para Menopause-Related Sleep Disturbance

Saffron (Crocus sativus) D

Hops para outras condições

Insônia A Dificuldade para Adormecer A

Veredito Rápido

Based on 8 studies (1 meta-analysis, 3 RCTs) with 2,688 total participants. 6/8 studies show positive effects.

Evidence Strength92%

High confidence

Detalhamento dos Estudos

RCT (2)Meta (0)Other (6)

Comparar Alternativas

Veja como outros ingredientes se comparam para esta condição.

Ver todos os ingredientes para Menopause-Related Sleep Disturbance

Saiba Mais

References

[1] Nathalie Schicktanz et al.. Brain Behav. 2025. Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: … doi:10.1002/brb3.70600 PubMed
[2] Christina N Wysota et al.. Health Educ Res. 2022. Young adults' knowledge, perceptions and use of cannabidiol products: a mixed-methods study. doi:10.1093/her/cyac030 PubMed
[3] Diana Lelli et al.. Adv Exp Med Biol. 2021. Use of Plant-Derived Natural Products in Sleep Disturbances. doi:10.1007/978-3-030-64872-5_15 PubMed
[4] Hyeon-Son Choi et al.. Biol Pharm Bull. 2017. Effect of Valerian/Hop Mixture on Sleep-Related Behaviors in Drosophila melanogaster. doi:10.1248/bpb.b17-00262 PubMed
[5] Larry Culpepper et al.. Prim Care Companion CNS Disord. 2015. Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient Insomnia: A Systematic Review of Efficacy and Safety. doi:10.4088/PCC.15r01798 PubMed
[6] Shanah Salter et al.. Aust Fam Physician. 2010. Treating primary insomnia - the efficacy of valerian and hops. PubMed
[7] Andrew D Krystal. J Clin Sleep Med. 2007. Treating the health, quality of life, and functional impairments in insomnia. PubMed
[8] Charles M Morin et al.. Sleep. 2005. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. doi:10.1093/sleep/28.11.1465 PubMed

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.

Hops para Menopause-Related Sleep Disturbance

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Conclusão

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Dosagens Comumente Utilizadas

Dosagens Estudadas em Pesquisas

Safety & Side Effects

Efeitos Colaterais Relatados

Interações Conhecidas

Frequently Asked Questions

Related Evidence

Outros ingredientes para Menopause-Related Sleep Disturbance

Hops para outras condições

References