Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial hypertension.

T Dyckner, P O Wester, L Widman

RCT European journal of clinical pharmacology 1986 22 citations

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Study Design

Study Type: Randomized Controlled Trial
Sample Size: 48
Population: hypertensive patients
Duration: 26.0 weeks

Intervention: Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial hypertension. 100 mg/d
Comparator: control group
Primary Outcome: blood pressure
Effect Direction: Mixed
Risk of Bias: Moderate

Abstract

The effect of adding spironolactone (Aldactone) on muscle electrolytes was studied in 48 patients with arterial hypertension and/or congestive heart failure who had received conventional diuretic treatment, including a potassium supplement, for more than 1 year. After 6 months on spironolactone 100 mg/day as well as the original conventional diuretic therapy, there was a significant increase in both skeletal muscle potassium and magnesium. At the same time these parameters decreased in the control group. In the spironolactone group there was also a significant increase in the mean serum potassium and creatinine levels. There was a significant fall in blood pressure in the spironolactone-treated group.

TL;DR

After 6 months on spironolactone 100 mg/day as well as the original conventional diuretic therapy, there was a significant increase in both skeletal muscle potassium and magnesium and these parameters decreased in the control group.

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Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial hypertension.

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Abstract

TL;DR

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