Pathophysiology of restless legs syndrome: evidence for iron involvement.
James R Connor
Review
Current neurology and neuroscience reports
2008
PubMed
DOI
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Abstract
Neuroimaging, analysis of cerebrospinal fluid, and studies on postmortem tissue are generating data that support the concept that iron availability to the brain is a contributory process to, if not a cause of, restless legs syndrome. These data are reviewed and related to the dopaminergic system because of the use of dopamine agents in treating restless legs syndrome.
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