Melatonin and clinical application.

L Wetterberg

Review Reproduction, nutrition, development 1999 64 citations

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Study Design

Study Type: Review

Intervention: Melatonin and clinical application. None
Comparator: Placebo
Effect Direction: Positive
Risk of Bias: Unclear

Abstract

A review of the different publications dealing with melatonin in humans shows that this field has been very active in the last few years. Normative melatonin values have been defined. Various relationships between melatonin and other traits have been studied, such as sleep, circadian rhythm, surgical stress and anaesthesia. Age-related melatonin studies and melatonin during depression and other psychiatric disorders have been reviewed. Finally, some studies have been performed to use melatonin as a medication for sleep disturbance in depression, for jet-lag and as a skin protector for ultraviolet light.