Mélatonine pour Décalage Horaire (Jet Lag)

Q: Does Mélatonine help with Décalage Horaire (Jet Lag)?

Based on 108 studies with 676 participants, there is strong evidence from multiple clinical trials that Mélatonine may support Décalage Horaire (Jet Lag) management. Our evidence grade is A (Strong Evidence).

Q: How much Mélatonine should I take for Décalage Horaire (Jet Lag)?

Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Mélatonine?

Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Mélatonine and Décalage Horaire (Jet Lag)?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 108 peer-reviewed studies with 676 total participants. The overall direction of effect is mixed.

Basé sur 57 études (6 meta-analyses, 2 RCTs) avec 516 participants au total. 35/57 études montrent des effets positifs.

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En conclusion

Melatonin is well-supported by research as a supplement that may help your body adjust to new time zones and reduce jet lag symptoms.

57 studies including 6 meta-analyses support melatonin for jet lag
Timing matters — taking melatonin near target bedtime at your destination may work best
One of the most widely recognized and studied uses for melatonin
About 61% of studies show clearly positive effects on jet lag symptoms

Key Study Findings

Review

Melatonin dose and timing: Do we have it right?

Dose: None vs: None Outcome: None Effet: None None

Population: Review of melatonin dose and timing

In Vitro

Exogenous L-Cysteine and Its Transport Through CtaP Play a Role in Biofilm Formation, Swimming Motility, …

Dose: 1.57 and 3.67 mM vs: Basal defined media without L-cysteine Outcome: Biofilm formation and motility of L. monocytogenes Effet: None None

Population: Listeria monocytogenes 10403S and ctaP mutant

review

Therapeutic Dilemma: Melatonin or not?

Dose: low doses melatonin (unspecified); melatonin for jet lag (adults) vs: Placebo Effet: None None

Controlled Clinical Trial n=24 2 weeks

D-Ribose-L-Cysteine protects against sodium arsenite-induced hepato-nephrotoxicity in rats.

Dose: 10 mg/kg body weight vs: Sodium arsenite group (SA, no riboceine) Outcome: Hepato-nephrotoxicity markers (ALT, AST, creatinine) Effet: None None

Population: Rats with sodium arsenite-induced toxicity

Other

Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing.

Dose: None vs: Wounds without hydrogel Outcome: Wound healing and circadian rhythm modulation Effet: None None

Population: Animal wound model with circadian disruption

Observational Study n=140

Association between behavioral jet lag with subjective and objective circadian rhythm among Chinese young adults.

Dose: None vs: Low behavioral jet lag group Outcome: rMEQ score and DLMO timing Effet: 1h social jet lag: -2.27 rMEQ, +24min DLMO delay <0.05

Population: Chinese young adults (mean age 20.7, 60% women)

Key Statistics

108

Études

676

Participants

↔

Mixed

Note

Referenced Papers

Do Long-Haul Travel and Jet Lag Affect Athletes' Physiological, Humoral and Performance Outcomes? A Systematic Narrative Review. Review

Sports (Basel, Switzerland) 2026

Association between behavioral jet lag with subjective and objective circadian rhythm among Chinese young adults. Other

Social science & … 2025 4 citations

Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing. Other

ACS applied bio … 2025 4 citations

Melatonin dose and timing: Do we have it right? Review

CNS spectrums 2025 1 citations

Exogenous L-Cysteine and Its Transport Through CtaP Play a Role in Biofilm Formation, Swimming Motility, and Swarming Motility of Listeria … Other

Foods (Basel, Switzerland) 2025 1 citations

Therapeutic Dilemma: Melatonin or not? Other

Paediatrics & child … 2025

D-Ribose-L-Cysteine protects against sodium arsenite-induced hepato-nephrotoxicity in rats. Other

Nigerian journal of … 2025

Bidirectional Crosstalk Between Sleep and Pulmonary Arterial Hypertension. Other

bioRxiv : the … 2025

Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes. Review

Diabetes & metabolism … 2024 18 citations

Circadian disruption reduces MUC4 expression via the clock molecule BMAL1 during dry eye development. Other

Experimental & molecular … 2024 14 citations

Circadian rhythms and breast cancer: from molecular level to therapeutic advancements. Review

Journal of cancer … 2024 11 citations

Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice. Other

Journal of pineal … 2024 9 citations

Insufficient Sleep Syndrome in Childhood. Review

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International journal of … 2023 146 citations

Melatonin from Microorganisms, Algae, and Plants as Possible Alternatives to Synthetic Melatonin. Review

Metabolites 2023 32 citations

Physiological and pharmacological perspectives of melatonin. Review

Archives of physiology … 2022 69 citations

Treatment of Circadian Rhythm Sleep-Wake Disorders. Review

Current neuropharmacology 2022 40 citations

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Methods to Assess Melatonin Receptor-Mediated Phase-Shift and Re-entrainment of Rhythmic Behaviors in Mouse Models. Other

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Biological Rhythm and Chronotype: New Perspectives in Health. Review

Biomolecules 2021 280 citations

Circadian Rhythm Sleep-Wake Disorders: a Contemporary Review of Neurobiology, Treatment, and Dysregulation in Neurodegenerative Disease. Review

Neurotherapeutics : the … 2021 73 citations

Evening wear of blue-blocking glasses for sleep and mood disorders: a systematic review. Systematic Review

Chronobiology international 2021 47 citations

The Potential Oncostatic Effects of Melatonin against Prostate Cancer. Review

Critical reviews in … 2021 3 citations

Novel Approaches for Assessing Circadian Rhythmicity in Humans: A Review. Review

Journal of biological … 2020 110 citations

How to manage travel fatigue and jet lag in athletes? A systematic review of interventions. Systematic Review

British journal of … 2020 56 citations

Evening types have social jet lag and metabolic alterations in school-age children. Other

Scientific reports 2020 50 citations

The effect of jet lag on the human brain: A neuroimaging study. Other

Human brain mapping 2020 15 citations

Melatonin for jet lag. Review

Drug and therapeutics … 2020 1 citations

Structural basis of ligand recognition at the human MT1 melatonin receptor. Other

Nature 2019 186 citations

Resetting the late timing of 'night owls' has a positive impact on mental health and performance. RCT

Sleep medicine 2019 102 citations

Nutrition for Travel: From Jet lag To Catering. Review

International journal of … 2019 29 citations

Advice for travelers. Review

The Medical letter … 2019

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. Review

British journal of … 2018 685 citations

Synchronizing effects of melatonin on diurnal and circadian rhythms. Review

General and comparative … 2018 136 citations

Approaches to the Pharmacological Management of Jet Lag. Review

Drugs 2018 56 citations

Jetlag related sleep problems and their management: A review. Review

Travel medicine and … 2018 27 citations

[CME: Jet Lag Jetlag]. Case Report

Praxis 2018 1 citations

Meal Timing Regulates the Human Circadian System. Other

Current biology : … 2017 455 citations

Melatonin Natural Health Products and Supplements: Presence of Serotonin and Significant Variability of Melatonin Content. Other

Journal of clinical … 2017 226 citations

Circadian Rhythm Sleep-Wake Disorders. Review

Continuum (Minneapolis, Minn.) 2017 132 citations

Chronomedicine and type 2 diabetes: shining some light on melatonin. Review

Diabetologia 2017 71 citations

Melatonin restores hippocampal neural precursor cell proliferation and prevents cognitive deficits induced by jet lag simulation in adult mice. Other

Journal of pineal … 2017 45 citations

Sleep Disorders: Circadian Rhythm Sleep-Wake Disorders. Review

FP essentials 2017 15 citations

Disruption of adolescents' circadian clock: The vicious circle of media use, exposure to light at night, sleep loss and risk … Review

Journal of physiology, … 2016 238 citations

Melatonin has multiorgan effects. Review

European heart journal. … 2016 77 citations

Keeping circadian time with hormones. Review

Diabetes, obesity & … 2015 132 citations

Sleep habits and diabetes. Review

Diabetes & metabolism 2015 112 citations

Jet Lag and Shift Work Disorder. Review

Sleep medicine clinics 2015 75 citations

Short-term incubation of bovine placentome sections as a tool to study xenobiotic mechanism of action. Other

Reproductive biology 2015 6 citations

Is melatonin useful for jet lag? Meta-Analysis

Medwave 2015 6 citations

Melatonin: an internal signal for daily and seasonal timing. Review

Indian journal of … 2014

Jet lag. Systematic Review

BMJ clinical evidence 2014

Effects of chronic jet lag on the central and peripheral circadian clocks in CBA/N mice. Other

Chronobiology international 2014

Chronobiology of the neuroimmunoendocrine system and aging. Review

Current pharmaceutical design 2014

Circadian rhythm abnormalities. Case Report

Continuum (Minneapolis, Minn.) 2013 172 citations

Air travel: effects of sleep deprivation and jet lag. Review

Chest 2013 53 citations

Melatonin: comprehensive profile. Review

Profiles of drug … 2013 26 citations

[Circadian rhythm sleep disorder]. Review

Nihon rinsho. Japanese … 2013

Circadian typology: a comprehensive review. Review

Chronobiology international 2012 1248 citations

Circadian rhythms and tumor growth. Review

Cancer letters 2012 108 citations

Melatonin: an underappreciated player in retinal physiology and pathophysiology. Review

Experimental eye research 2012

Jet lag and shift work sleep disorders: how to help reset the internal clock. Review

Cleveland Clinic journal … 2011 73 citations

Excitotoxicity triggered by Neurobasal culture medium. Other

PloS one 2011 39 citations

Perioperative melatonin use. Review

Anaesthesia and intensive … 2011 18 citations

[Jet lag disorders]. Review

La Revue de … 2011 3 citations

[Rheumatism, jet lag and the body clock]. Review

Zeitschrift fur Rheumatologie 2011

Update on the use of melatonin in pediatrics. Review

Journal of pineal … 2011

Jet lag: current and potential therapies. Other

P & T … 2011

Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. Review

Advances in therapy 2010 136 citations

Clinical practice. Jet lag. Review

The New England … 2010 130 citations

Melatonin agonists and insomnia. Review

Expert review of … 2010 58 citations

Melatonin: pharmacological aspects and clinical trends. Review

The International journal … 2010 55 citations

Come fly with me: jet lag and melatonin. Other

International journal of … 2010 5 citations

Ready for takeoff? A critical review of armodafinil and modafinil for the treatment of sleepiness associated with jet lag. Other

Nature and science … 2010 3 citations

Treatment of shift work disorder and jet lag. Other

Current treatment options … 2010

Jet lag syndrome: circadian organization, pathophysiology, and management strategies. Other

Nature and science … 2010

Complementary and alternative medicine usage for behavioral health indications. Review

Primary care 2010

Clinical uses of melatonin: evaluation of human trials. Review

Current medicinal chemistry 2010

Managing jet lag: Some of the problems and possible new solutions. Review

Sleep medicine reviews 2009 141 citations

The pathophysiology of jet lag. Review

Travel medicine and … 2009 101 citations

Melatonin and its relevance to jet lag. Review

Travel medicine and … 2009 60 citations

Circadian rhythm disorders. Review

Seminars in neurology 2009 17 citations

[Circadian rhythm sleep disorders]. Review

Tidsskrift for den … 2009 6 citations

Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders. Other

Current opinion in … 2009

Melatonin for primary insomnia? Review

Drug and therapeutics … 2009

["Jet-lag"--pathophysiology and methods of prevention and treatment]. Review

Przeglad epidemiologiczny 2009

The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders. Review

Nature clinical practice. … 2008 139 citations

Melatonergic drugs in clinical practice. Review

Arzneimittel-Forschung 2008 89 citations

Jet lag: therapeutic use of melatonin and possible application of melatonin analogs. Review

Travel medicine and … 2008 84 citations

Clinical aspects of melatonin. Review

Saudi medical journal 2008

Jet lag. Systematic Review

BMJ clinical evidence 2008

Jet lag: trends and coping strategies. Review

Lancet (London, England) 2007 405 citations

A clinical approach to circadian rhythm sleep disorders. Review

Sleep medicine 2007 201 citations

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Cellular and molecular … 2007 88 citations

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The American journal … 2007 3 citations

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Light at night, chronodisruption, melatonin suppression, and cancer risk: a review. Review

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CNS spectrums 2003 29 citations

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Maturitas 2002 59 citations

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Jet lag: minimizing it's effects with critically timed bright light and melatonin administration. Review

Journal of molecular … 2002

Jet lag in athletes after eastward and westward time-zone transition. Other

Chronobiology international 2002

Melatonin in sleep disorders and jet-lag. Review

Neuro endocrinology letters 2002

Human aging and melatonin. Clinical relevance. Review

Experimental gerontology 2001 178 citations

Melatonin for preventing and treating jet lag. Systematic Review

The Cochrane database … 2001 154 citations

Circadian rhythm sleep disorders: pathophysiology and potential approaches to management. Review

CNS drugs 2001 135 citations

Melatonin, light therapy, and jet lag. Review

Air medical journal 2001 12 citations

Effectiveness and tolerability of melatonin and zolpidem for the alleviation of jet lag. RCT

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Reproduction, nutrition, development 1999 64 citations

The use of melatonin for the treatment of insomnia. Review

Biological signals and … 1999 48 citations

Circadian Rhythm Sleep Disorders. Other

Current treatment options … 1999 23 citations

Use of melatonin in the treatment of phase shift and sleep disorders. Review

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European journal of … 1999

Jet-lag and shift work: (2). Therapeutic use of melatonin. Review

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British journal of … 1998 17 citations

Melatonin for jet lag? Review

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[Jet lag syndrome]. Review

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Efficacy of melatonin treatment in jet lag, shift work, and blindness. Review

Journal of biological … 1997 255 citations

Treatment of circadian rhythm disorders--melatonin. Review

Chronobiology international 1997 135 citations

[Jet lag]. Review

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Effect of melatonin on jet lag after long haul flights. RCT

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Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

general:: 0.5-3 mg, 30-60 min before bed
jetlag:: 0.5-5 mg

Limite supérieure : No established UL; 5 mg typically considered maximum

Posologies étudiées dans la recherche

Posologie	Durée	Effet	N
None	--	Mixed	--
1.57 and 3.67 mM	--	Mixed	--
low doses melatonin (unspecified); melatonin for jet lag (adults)	--	Positive	--
10 mg/kg body weight	2 weeks	Positive	24
None	--	Positive	--
None	--	Negative	140
None	--	Positive	--
None	--	Neutral	--

Moment optimal de prise : 30-60 minutes before bed

Safety & Side Effects

Effets indésirables signalés

⚠ Daytime drowsiness
⚠ Headache
⚠ Dizziness
⚠ Nausea
⚠ Vivid dreams or nightmares

Interactions connues

● Blood thinners (warfarin) — may increase bleeding risk
● Immunosuppressants — melatonin may stimulate immune function
● Diabetes medications — may affect blood sugar levels
● Sedatives and CNS depressants — additive drowsiness

Apport maximal tolérable : No established UL; 5 mg typically considered maximum

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does Mélatonine help with Décalage Horaire (Jet Lag)?

Based on 108 studies with 676 participants, there is strong evidence from multiple clinical trials that Mélatonine may support Décalage Horaire (Jet Lag) management. Our evidence grade is A (Strong Evidence).

How much Mélatonine should I take for Décalage Horaire (Jet Lag)?

Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Mélatonine?

Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Mélatonine and Décalage Horaire (Jet Lag)?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 108 peer-reviewed studies with 676 total participants. The overall direction of effect is mixed.

Related Evidence

Mélatonine pour d'autres pathologies

Insomnie A Trouble du Rythme Circadien A Trouble du Sommeil Lié au Travail Posté A Difficulté d'Endormissement A Changements du Sommeil Liés à l'Âge B

Verdict rapide

Basé sur 57 études (6 meta-analyses, 2 RCTs) avec 516 participants au total. 35/57 études montrent des effets positifs.

Evidence Strength92%

High confidence

Synthèse des études

RCT (3)Meta (1)Other (104)

Comparer les alternatives

Découvrez comment d'autres ingrédients se comparent pour cette condition.Découvrez comment d'autres ingrédients se comparent pour cette pathologie.

Voir tous les ingrédients pour Décalage Horaire (Jet Lag)

En savoir plus

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.