5-HTP for Insomnia
B ModerateBased on 31 studies (1 RCT) with 83 total participants. 25/31 studies show positive effects.
Key Statistics
31
Studies
83
Participants
Positive
Grade
Referenced Papers
Dosage & Usage
Commonly Used Dosages
- sleep:
- 100-300 mg, 30-45 min before bed
Upper limit: Not established; serotonin syndrome risk with SSRIs
Dosages Studied in Research
| Dosage | المدّة | Effect | N |
|---|---|---|---|
| Cinnamic acid (CA) administered to rats (dose not specified) | -- | Positive | -- |
| 5-HTP encapsulated in β-cyclodextrin/corn starch composite nanoparticles (dose not specified) | -- | Positive | -- |
| Fushen Decoction 10, 20, and 40 g/kg; coffee 1 g/kg (PCPA-induced insomnia model) | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| various 5-HT1A and 5-HT7 receptor ligands (aminotetralins, ergolines, arylpiperazines, indolylalkyla | -- | Neutral | -- |
| None | -- | Positive | -- |
Best taken: 30-45 minutes before bed
Safety & Side Effects
Reported Side Effects
- ⚠ Nausea
- ⚠ Diarrhea
- ⚠ Heartburn
- ⚠ Stomach pain
- ⚠ Drowsiness
Known Interactions
- ● SSRIs/SNRIs — serious risk of serotonin syndrome
- ● MAOIs — dangerous serotonin accumulation
- ● Tramadol — increased serotonin syndrome risk
- ● Carbidopa — may cause scleroderma-like skin changes
Tolerable upper intake: Not established; serotonin syndrome risk with SSRIs
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
Does 5-HTP help with Insomnia?
How much 5-HTP should I take for Insomnia?
Are there side effects of 5-HTP?
How strong is the evidence for 5-HTP and Insomnia?
Related Evidence
Other ingredients for Insomnia
5-HTP for other conditions
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.