Mô tả
Clinical applications of melatonin extend beyond sleep induction to include circadian rhythm resynchronization in jet lag, shift work disorder, and delayed sleep-wake phase disorder. Dose-response relationships vary across these conditions.
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Figure 2
Circadian rhythm regulation involves a complex interplay between the central clock in the suprachiasmatic nuclei and peripheral oscillators throughout the body. Melatonin serves as the primary hormonal signal conveying darkness information to these systems.
diagram
Figure 3
Exogenous melatonin administration influences circadian phase positioning, with the direction and magnitude of phase shifts depending on the timing of administration. Evening doses advance the circadian clock, while morning doses may cause phase delays.
chartFigure 4
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New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation.Cite This Figure
 > Source: Nava Zisapel "New perspectives on the role of melatonin in human sleep, circadian rhythms and ." *British journal of pharmacology*, 2018. PMID: [29318587](https://pubmed.ncbi.nlm.nih.gov/29318587/)
<figure> <img src="https://pdfs.citedhealth.com/figures/29318587/134.png" alt="Clinical applications of melatonin extend beyond sleep induction to include circadian rhythm resynchronization in jet lag, shift work disorder, and delayed sleep-wake phase disorder. Dose-response relationships vary across these conditions." /> <figcaption>Figure 4. Clinical applications of melatonin extend beyond sleep induction to include circadian rhythm resynchronization in jet lag, shift work disorder, and delayed sleep-wake phase disorder. Dose-response relationships vary across these conditions.<br> Source: Nava Zisapel "New perspectives on the role of melatonin in human sleep, circadian rhythms and ." <em>British journal of pharmacology</em>, 2018. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/29318587/">29318587</a></figcaption> </figure>