[Insomnia induced by P-chlorophenylalanine in cats. Its reversibility by intraventricular injections of indolamines].

F Petitjean, C Buda, M Janin, M Sallanon, M Jouvet

Other Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles 1980 1 цитирований

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Study Design

Тип исследования: Animal Study

Вмешательство: [Insomnia induced by P-chlorophenylalanine in cats. Its reversibility by intraventricular injections of indolamines]. 250 micrograms of 5-HTP intraventricular injection
Препарат сравнения: Placebo
Направление эффекта: Positive
Риск систематической ошибки: Unclear

Abstract

Intraventricular injection of 250 microgram of 5 HTP induces both slow wave and paradoxical sleep, after 20-60 min. latencies, in insomniac Cats pretreated with P-chlorophenylalanine. Direct injections of 5 HTP in several brain stem structures do not induce sleep. The long latency or paradoxical sleep induction and its suppression with chloramphenicol suggest that indolamines are not directly responsible for paradoxical sleep, but that they act by controlling the synthesis and/or the liberation in the periventricular system of some specific paradoxical sleep inducing factor.

Used In Evidence Reviews

A Триптофан для Бессонница

B 5-HTP для Бессонница

[Insomnia induced by P-chlorophenylalanine in cats. Its reversibility by intraventricular injections of indolamines].

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Study Design

Abstract

Used In Evidence Reviews

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