Restless legs syndrome and pregnancy.

M Manconi, V Govoni, A De Vito, N T Economou, E Cesnik et al.

Other Neurology 2004 386 citations

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Study Design

Study Type: Observational Study
Sample Size: 642
Population: Pregnant women
Duration: 26 weeks

Intervention: Restless legs syndrome and pregnancy. None
Comparator: None
Primary Outcome: RLS prevalence during pregnancy
Effect Direction: Mixed
Risk of Bias: Moderate

Abstract

OBJECTIVE: To perform a large and detailed epidemiologic study on restless legs syndrome (RLS) during pregnancy and the puerperium. METHODS: A structured clinical interview, assessing symptoms since the beginning of pregnancy, was performed to a population of 642 pregnant women at the time of delivery and at follow-up evaluation (1, 3, and 6 months after delivery). Main hematologic tests were also evaluated. A woman was considered affected if she met the International RLS Study Group criteria for RLS diagnosis. RESULTS: Twenty-six percent of women were affected by RLS during their pregnancy. The disease was strongly related to the third trimester of pregnancy and tended to disappear reaching the time of delivery. Affected women presented lower values of hemoglobin and mean corpuscular volume compared with healthy subjects (both groups received the same supplemental iron and folate therapy). CONCLUSIONS: Pregnancy is associated with transient restless legs syndrome.

TL;DR

Pregnancy is associated with transient restless legs syndrome, and affected women presented lower values of hemoglobin and mean corpuscular volume compared with healthy subjects.

Used In Evidence Reviews

A Iron for Restless Leg Syndrome

Restless legs syndrome and pregnancy.

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Study Design

Abstract

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