Skip to main content
SleepCited

研究プロセス

42 査読済み研究からの図表

すべて アピゲニン メラトニン ラベンダー アシュワガンダ トリプトファン ホーリーバジル バレリアンルート パッションフラワー オメガ3脂肪酸 5-HTP ビタミンB6 CBD ビタミンD GABA 亜鉛 グリシン酸マグネシウム 鉄 Kava
All Types Chart Diagram Photograph Flowchart Forest Plot Micrograph Other
Figure 2
Figure 3 Chart

Exogenous melatonin administration influences circadian phase positioning, with the direction and magnitude of phase shifts depending on the timing of administration. Evening doses advance the circadian clock, while morning doses may cause phase delays.

New perspectives on the role of melatonin in human sleep, circadian rhythms …

Figure 3
Figure 4 Chart

Clinical applications of melatonin extend beyond sleep induction to include circadian rhythm resynchronization in jet lag, shift work disorder, and delayed sleep-wake phase disorder. Dose-response relationships vary across these conditions.

New perspectives on the role of melatonin in human sleep, circadian rhythms …

Figure 3
Figure 3 Chart

Hormonal response profiles to standardized meals are compared between normal and delayed meal timing conditions, revealing shifts in metabolic hormone rhythms.

Meal Timing Regulates the Human Circadian System.

Figure 4
Figure 4 Chart

Average plasma glucose concentration under constant routine conditions is reduced following a 5-hour delay in meal times, suggesting meal timing significantly influences glucose metabolism rhythms.

Meal Timing Regulates the Human Circadian System.

Figure 5
Figure 5 Chart

Core body temperature rhythms are displayed across experimental conditions, demonstrating that meal timing shifts selectively affect peripheral but not central circadian markers.

Meal Timing Regulates the Human Circadian System.

Figure 4. The Average Plasma Glucose Concentration in Constant Routine Conditions Is Reduced Following a 5-hr Delay in Meal Times
Figure 6 Chart

Plasma glucose concentrations during constant routine conditions show a significant reduction after participants experienced delayed meal times, indicating that meal scheduling influences circadian glucose regulation.

Meal Timing Regulates the Human Circadian System.

Figure 7
Figure 7 Chart

Clock gene expression patterns in adipose tissue are compared between the two meal timing conditions, revealing tissue-specific circadian phase shifts.

Meal Timing Regulates the Human Circadian System.

Figure 8
Figure 8 Chart

Per2 and other clock gene transcript levels measured from peripheral blood samples demonstrate delayed phase alignment consistent with the shifted meal schedule.

Meal Timing Regulates the Human Circadian System.

Figure 2
Figure 2 Chart

Efficacy outcomes showing changes in sleep parameters over the extended treatment period with pediatric prolonged-release melatonin in children with ASD. Long-term data indicate sustained improvements in sleep onset latency and total sleep time.

Long-Term Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children …

Figure 3
Figure 3 Chart

Safety assessment data from the open-label extension of PedPRM treatment in pediatric patients with autism spectrum disorder. Adverse event profiles suggest the prolonged-release melatonin formulation maintained an acceptable safety profile over the extended study period.

Long-Term Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children …

Figure 4
Figure 4 Chart

Summary of sleep quality measures or caregiver-reported outcomes during long-term PedPRM administration in children with ASD and comorbid insomnia. Results suggest continued therapeutic benefit with nightly melatonin use.

Long-Term Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children …

Fig. 1 Mean 24 h melatonin levels in HD patients and matched controls. The diurnal melatonin rise was significantly delayed in HD patients by about 01:30 h (p = 0.048). The black bar on the abscissa indicates the dark period (23:00–7:30 h)
Figure 1 Chart

Mean 24-hour melatonin profiles in Huntington's disease patients and matched healthy controls are plotted, revealing a statistically significant delay of approximately 1.5 hours in the diurnal melatonin rise among HD patients (p = 0.048).

Delayed onset of the diurnal melatonin rise in patients with Huntington's disease.

Figure 2. Risk of bias included in the study.
Figure 3 Chart

Risk of bias assessment across included studies evaluates methodological quality domains such as randomization, blinding, and outcome reporting in aroma therapy trials.

A systematic literature review and meta-analysis of the clinical effects of aroma …

Figure 3. The risk of bias using RevMan.
Figure 4 Chart

Traffic-light visualization of risk of bias for individual studies included in the aroma inhalation therapy meta-analysis, generated using RevMan software, reveals varying methodological quality.

A systematic literature review and meta-analysis of the clinical effects of aroma …

Figure 4. Funnel plot of the publication bias.
Figure 5 Chart

Funnel plot analysis assesses potential publication bias among studies included in the meta-analysis of aroma inhalation therapy for sleep problems, with symmetry indicating low risk.

A systematic literature review and meta-analysis of the clinical effects of aroma …

Figure 6. The regression analysis of aroma therapy program according to years about for the slope of the primary outcome.
Figure 7 Chart

Meta-regression analysis examines whether the effectiveness of aroma inhalation therapy for sleep problems varies by program duration or publication year, revealing trends in the slope of the primary outcome.

A systematic literature review and meta-analysis of the clinical effects of aroma …

Figure 5
Figure 5 Chart

Overall quality assessment of commercial veterinary hemp supplements integrates cannabinoid accuracy, heavy metal safety, and terpene characterization. Substantial product-to-product variability underscores the need for standardized manufacturing.

Cannabinoid, Terpene, and Heavy Metal Analysis of 29 Over-the-Counter Commercial Veterinary Hemp …

Figure 4
Figure 4 Chart

Dose-response analysis of melatonin supplementation on sleep parameters, indicating that lower physiological doses may be as effective as higher pharmacological doses for circadian rhythm regulation.

Melatonin as a Chronobiotic with Sleep-promoting Properties.

Figure 5
Figure 5 Chart

Circadian phase-response curve for exogenous melatonin, demonstrating how timing of administration determines whether it advances or delays the circadian clock.

Melatonin as a Chronobiotic with Sleep-promoting Properties.

Fig 1. Sphere-forming efficiency decreases following radiation. A single 5 Gy dose of radiation (IR d30) was given to 4–6 week old female FVB mice and parotid glands were collected 30 days following radiation for sphere formation assay. Representative bri
Figure 2 Chart

Sphere-forming efficiency of parotid-derived cells decreases significantly following a single 5 Gy radiation dose, quantified at day 30 post-irradiation.

Administration of growth factors promotes salisphere formation from irradiated parotid salivary glands.

Fig 2. Similar proliferation rates are observed in untreated and irradiated salispheres cultured in serum-free conditions. Untreated and irradiated parotid-derived salispheres were fixed after 7 and 14 days in culture and stained for Ki-67 (green). Repres
Figure 3 Chart

Proliferation rates of salisphere cultures from untreated and irradiated parotid glands are compared under serum-free conditions, showing similar growth kinetics despite radiation damage.

Administration of growth factors promotes salisphere formation from irradiated parotid salivary glands.

Fig 4. Similar proliferation rates are observed in untreated and irradiated salisphere cultures supplemented with FBS. Untreated and irradiated parotid-derived salispheres, maintained under different FBS concentrations, were fixed after 4 and 7 days in cu
Figure 5 Chart

Proliferation assays confirm comparable growth rates between untreated and irradiated salisphere cultures supplemented with FBS, indicating that reduced sphere formation is not due to proliferation deficits.

Administration of growth factors promotes salisphere formation from irradiated parotid salivary glands.

Fig 5. Expression of salivary stem/progenitor markers by salisphere cells. Untreated and irradiated parotid-derived salispheres, maintained under different FBS concentrations, were fixed after 7 days in culture and stained for Keratin 5 (K5) or Keratin 14
Figure 6 Chart

Expression of salivary stem and progenitor cell markers in salisphere cultures demonstrates that both untreated and irradiated cells maintain their progenitor phenotype.

Administration of growth factors promotes salisphere formation from irradiated parotid salivary glands.

Fig 6. Post-radiation treatment with IGF1 increases sphere-forming efficiency of irradiated parotid-derived cells. A single 5 Gy dose of radiation was given to 4–6 week old or 8 week female FVB mice followed by injections of insulin growth factor 1 (IGF1)
Figure 7 Chart

Post-radiation IGF-1 treatment significantly enhances sphere-forming efficiency of irradiated parotid cells, suggesting growth factor administration as a strategy to restore salivary function.

Administration of growth factors promotes salisphere formation from irradiated parotid salivary glands.

2ページ中1ページ目