Neuroimaging in Restless Legs Syndrome.

Federica Provini, Giacomo Chiaro

Review Sleep medicine clinics 2015 29 citations

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Study Design

Type d'étude: Review
Population: restless legs syndrome patients

Intervention: Neuroimaging in Restless Legs Syndrome. None
Comparateur: None
Critère de jugement principal: None
Direction de l'effet: Mixed
Risque de biais: Unclear

Abstract

Neuroimaging studies are of crucial relevance in defining the pathophysiology of restless legs syndrome (RLS). MRI studies showed no structural brain lesions and confirmed a central iron deficiency. Structural and functional studies showed an involvement of the thalamus, sensorimotor cortical areas, and cerebellum in RLS and assessed neurotransmission abnormalities in the dopaminergic and opiate systems. Finally, glutamatergic hyperactivity has been proposed as a cause of disrupted and shortened sleep in RLS. Differences among the results of the studies make it difficult to draw any definitive conclusions, thus, suggesting the need for future research.

En bref

Differences among the results of the studies make it difficult to draw any definitive conclusions, thus, suggesting the need for future research.

Used In Evidence Reviews

A Fer pour Syndrome des Jambes Sans Repos

Neuroimaging in Restless Legs Syndrome.

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Study Design

Abstract

En bref

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