Mechanism of action of tasimelteon in non-24 sleep-wake syndrome: treatment for a circadian rhythm disorder in blind patients.

Stephen M Stahl

Review CNS spectrums 2014 13 citations

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Study Design

Type d'étude: Review
Population: Totally blind individuals with non-24 sleep-wake syndrome

Intervention: Mechanism of action of tasimelteon in non-24 sleep-wake syndrome: treatment for a circadian rhythm disorder in blind patients. None
Comparateur: None
Critère de jugement principal: Non-24 sleep-wake syndrome in blind patients
Direction de l'effet: Positive
Risque de biais: Unclear

Abstract

Many individuals with total blindness can develop a circadian rhythm disorder-called non-24 sleep wake syndrome-because they cannot detect light to resynchronize their sleep-wake cycles. A new melatonin 1 and melatonin 2 agonist tasimelteon improves sleep in these patients, resetting their circadian sleep-wake clocks.

En bref

A new melatonin 1 and melatonin 2 agonist tasimelteon improves sleep in patients with total blindness, resetting their circadian sleep–wake clocks.

Used In Evidence Reviews

A Mélatonine pour Trouble du Rythme Circadien

Mechanism of action of tasimelteon in non-24 sleep-wake syndrome: treatment for a circadian rhythm disorder in blind patients.

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Study Design

Abstract

En bref

Used In Evidence Reviews

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