Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology.
Richard P Allen
Review
Sleep medicine clinics
2015
158 trích dẫn
Thiết kế nghiên cứu
- Loại nghiên cứu
- Review
- Đối tượng nghiên cứu
- Patients with restless leg syndrome/Willis-Ekbom disease
- Can thiệp
- Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology.
- Đối chứng
- None
- Kết quả chính
- Pathophysiology of restless leg syndrome/Willis-Ekbom disease
- Xu hướng hiệu quả
- Neutral
- Nguy cơ sai lệch
- Unclear
Tóm tắt
Restless leg syndrome/Willis-Ekbom disease has brain iron deficiency that produces excessive dopamine and known genetic risks, some of which contribute to the brain iron deficiency. Dopamine treatments work temporarily but may eventually produce further postsynaptic down-regulation and worse restless leg syndrome. This article includes sections focused on pathophysiologic findings from each of these areas: genetics, cortical-spinal excitability, and iron and dopamine.
Tóm lược
Part of this article includes sections focused on pathophysiologic findings from each of these areas: genetics, cortical-spinal excitability, and iron and dopamine.