Sleep disturbances in a case of brain-stem lesions; pharmacological study.

F Laffont, H P Cathala, A Ernst, M Bormer, D Schneider-Helmert et al.

Case Report Electroencephalography and clinical neurophysiology 1984 2 citazioni

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Study Design

Tipo di studio: Case report
Dimensione del campione: 1

Intervento: Sleep disturbances in a case of brain-stem lesions; pharmacological study. None
Comparatore: Placebo
Direzione dell'effetto: Positive
Rischio di bias: High

Abstract

A pharmacological study was carried out of a case of severe insomnia following brain-stem lesions; several polygraphic controls were used. Initially total duration of sleep was brief (less than 4 h) with a high REM/NREM ratio and a short paradoxical sleep (PS) latency. In addition, periodic breathing and tremor were observed. Slow injection of delta-sleep-inducing peptide (DSIP) improved sleep both quantitatively and qualitatively, although PS latency remained short. These effects were reversible. The effects of 5-HTP + benzerazide, of L-DOPA + benzerazide (Modopar) and of clonazepam (Rivotril) were compared.

Used In Evidence Reviews

A Acidi grassi Omega-3 per Insonnia

B 5-HTP per Insonnia

Sleep disturbances in a case of brain-stem lesions; pharmacological study.

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Study Design

Abstract

Used In Evidence Reviews

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