Phosphatidylserine
phospholipidAlso known as: PS, SerinAid
About
Phosphatidylserine is a phospholipid found in high concentrations in brain cell membranes. Research suggests it may support sleep by blunting the cortisol stress response through HPA axis modulation, potentially helping reduce evening cortisol levels that interfere with sleep.
How It Works
Blunts cortisol response to stress via HPA axis modulation; reduces evening cortisol for sleep facilitation.
Evidence For Conditions
| Condition | Grade | Studies | Participants | |
|---|---|---|---|---|
| Anxiety-Related Sleep Problems | D Preliminary | 0 | -- | View → |
Side Effects
- Insomnia at high doses (paradoxical)
- GI upset
- Nausea
Drug & Supplement Interactions
- Blood thinners — phosphatidylserine may have mild anticoagulant effects
- Anticholinergic drugs — may affect cholinergic signaling
- Alzheimer's medications (cholinesterase inhibitors) — potential interaction
Always inform your healthcare provider about all supplements you take.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.