CBD
cannabinoidAlso known as: Cannabidiol, Hemp extract
About
CBD (cannabidiol) is a non-intoxicating compound from the cannabis plant that interacts with the endocannabinoid system. Research on CBD for sleep is still emerging, with some studies suggesting it may support sleep primarily by reducing anxiety rather than direct sedation.
How It Works
Modulates endocannabinoid system; anxiolytic via 5-HT1A receptor agonism may reduce sleep-onset anxiety.
Side Effects
- Fatigue
- Diarrhea
- Changes in appetite
- Dry mouth
- Liver enzyme elevation at high doses
Drug & Supplement Interactions
- CYP3A4/CYP2C19 substrates — CBD inhibits these liver enzymes
- Blood thinners (warfarin) — CBD may increase warfarin levels
- Clobazam — CBD significantly increases clobazam levels
- Sedatives — additive drowsiness
Always inform your healthcare provider about all supplements you take.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.