SleepCited

Passionflower for Anxiety-Related Sleep Problems

A Strong

Based on 9 studies (4 meta-analyses) with 2,619 total participants. 8/9 studies show positive effects.

Key Statistics

9

Studies

2619

Participants

↑

Positive

A Strong

Grade

Referenced Papers

The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs. Review
Molecules (Basel, Switzerland) 2025 2 citations
Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. Meta-Analysis
Pharmacological research 2022 51 citations
Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep. Systematic Review
Nutrients 2021 85 citations
Medicinal Plants for Insomnia Related to Anxiety: An Updated Review. Review
Planta medica 2021 41 citations
GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Systematic Review
Phytotherapy research : … 2018 95 citations
Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Systematic Review
Nutrition journal 2010 187 citations
Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Review
Medical science monitor … 2009 85 citations
Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. Review
Journal of psychopharmacology … 2005 176 citations
Safety and efficacy of herbal sedatives in cancer care. Review
Integrative cancer therapies 2004 59 citations

Dosage & Usage

Commonly Used Dosages

sleep:
250-500 mg extract or 1-2 cups tea, before bed

Upper limit: Not established

Dosages Studied in Research

Dosage Duration Effect N
None -- Positive --
Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion -- Positive --
None -- Positive --
None -- Positive --

Best taken: 30-60 minutes before bed

Safety & Side Effects

Reported Side Effects

  • ⚠ Drowsiness
  • ⚠ Dizziness
  • ⚠ Confusion at high doses
  • ⚠ Nausea

Known Interactions

  • ● Sedatives and benzodiazepines — additive CNS depression
  • ● Blood thinners — passionflower may increase bleeding risk
  • ● MAOIs — passionflower contains harmala alkaloids

Tolerable upper intake: Not established

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Passionflower help with Anxiety-Related Sleep Problems?
Based on 9 studies with 2,619 participants, there is strong evidence from multiple clinical trials that Passionflower may support Anxiety-Related Sleep Problems management. Our evidence grade is A (Strong).
How much Passionflower should I take for Anxiety-Related Sleep Problems?
Studies have used various dosages. A commonly studied range is 250-500 mg extract or 1-2 cups tea, before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Passionflower?
Reported side effects may include Drowsiness, Dizziness, Confusion at high doses, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Passionflower and Anxiety-Related Sleep Problems?
We rate the evidence as Grade A (Strong). This rating is based on 9 peer-reviewed studies with 2,619 total participants. The overall direction of effect is positive.

Related Evidence

Passionflower for other conditions

Insomnia A Strong

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.