Glycine for Insomnia
A StrongBased on 27 studies (1 meta-analysis, 3 RCTs) with 483,400 total participants. 15/27 studies show positive effects.
Key Statistics
27
Studies
483400
Participants
Positive
Grade
Referenced Papers
Dosage & Usage
Commonly Used Dosages
- sleep:
- 3 g, 1 hour before bed
Upper limit: Not established; studied up to 9 g/day
Dosages Studied in Research
| Dosage | Duration | Effect | N |
|---|---|---|---|
| Lactobacillus reuteri E9 (dose not specified) | -- | Positive | -- |
| None | -- | Neutral | -- |
| Arachis hypogaea L. stems and leaves extract | -- | Positive | -- |
| various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa | -- | Positive | 451 |
| 15 g/day collagen peptides (glycine-rich) consumed 1 hour before bedtime for 7 nights | 1 weeks | Positive | 13 |
| None | 3 weeks | Positive | -- |
| None | -- | Positive | -- |
| GM 400 mg/kg; GE 30 mg/kg | -- | Positive | -- |
Best taken: 1 hour before bed
Safety & Side Effects
Reported Side Effects
- ⚠ Nausea
- ⚠ Soft stools
- ⚠ Mild drowsiness
Known Interactions
- ● Clozapine — glycine may reduce effectiveness of this antipsychotic
- ● Antihypertensives — potential additive blood pressure lowering
Tolerable upper intake: Not established; studied up to 9 g/day
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
Does Glycine help with Insomnia?
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How strong is the evidence for Glycine and Insomnia?
Related Evidence
Other ingredients for Insomnia
Glycine for other conditions
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