Melatonin
hormoneAlso known as: N-acetyl-5-methoxytryptamine
About
Melatonin is a hormone naturally produced by the pineal gland that plays a central role in regulating the sleep-wake cycle. Supplemental melatonin is widely researched for supporting sleep onset and adjusting circadian rhythm timing.
How It Works
Endogenous hormone that binds MT1/MT2 receptors in the SCN, regulating circadian rhythm and sleep onset.
Evidence For Conditions
| Condition | Grade | Studies | Participants | |
|---|---|---|---|---|
| Insomnia | A Strong | 119 | 44370 | Vista → |
| Circadian Rhythm Disorder | A Strong | 52 | 1773 | Vista → |
| Sleep Onset Difficulty | A Strong | 30 | 10634 | Vista → |
| Shift Work Sleep Disorder | A Strong | 26 | 1899 | Vista → |
| Jet Lag | B Moderate | 43 | 484 | Vista → |
| Age-Related Sleep Changes | D Preliminary | 0 | -- | Vista → |
Side Effects
- Daytime drowsiness
- Headache
- Dizziness
- Nausea
- Vivid dreams or nightmares
Drug & Supplement Interactions
- Blood thinners (warfarin) — may increase bleeding risk
- Immunosuppressants — melatonin may stimulate immune function
- Diabetes medications — may affect blood sugar levels
- Sedatives and CNS depressants — additive drowsiness
Always inform your healthcare provider about all supplements you take.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.