Glycine
amino_acidAlso known as: Aminoacetic acid
About
Glycine is a non-essential amino acid that serves as an inhibitory neurotransmitter in the central nervous system. Research suggests supplemental glycine may support sleep quality by lowering core body temperature through its action on NMDA receptors in the brain's circadian control center.
How It Works
Acts on NMDA receptors in SCN to lower core body temperature; also an inhibitory neurotransmitter in brainstem.
Evidence For Conditions
| Condition | Grade | Studies | Participants | |
|---|---|---|---|---|
| Insomnia | A Strong | 27 | 483400 | Vista → |
| Sleep Onset Difficulty | D Preliminary | 1 | 5 | Vista → |
Side Effects
- Nausea
- Soft stools
- Mild drowsiness
Drug & Supplement Interactions
- Clozapine — glycine may reduce effectiveness of this antipsychotic
- Antihypertensives — potential additive blood pressure lowering
Always inform your healthcare provider about all supplements you take.
Related Ingredients
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.