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Figure 4. Effects of administration of MSM, CRCE, or MSM/CRCE on intrahepatic expression of cytochrome P450s. Livers were collected 24 h after the last gavage and gene expression was measured using the quantitative real-time (qRT) PCR. Data was analyzed by
Figure 6. Figure 4. Effects of administration of MSM, CRCE, or MSM/CRCE on intrahepatic expression of cytochrome P450s. Livers were collected 24 h after the last gavage and gene expression was measured using the quantitative real-time (qRT) PCR. Data was analyzed by two-way ANOVA with Bonferroni post-test and presented as mean ± SD fold change from vehicle (n = 6–8), with * as p < 0.05; ** as p < 0.01, and *** as p < 0.001. MSM—methylsulfonylmethane, CRCE—cannabidiol-rich cannabis extract.

Beschreibung

Intrahepatic expression of cytochrome P450 enzymes in response to MSM, CBD-rich cannabis extract (CRCE), or their combination. Alterations in CYP450 expression are critical for assessing drug-supplement interaction potential and metabolic safety.

More Figures from This Paper

Extended molecular analysis data examining the effects of CBD-rich cannabis extract and MSM on cellular detoxification pathways. The results contribute to understanding the safety implications of co-supplementation.

Figure 5

Extended molecular analysis data examining the effects of CBD-rich cannabis extract and MSM on cellular detoxification pathways. The results contribute to understanding the safety implications of co-supplementation.

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Effects of MSM, CBD-rich cannabis extract, and their combination on intrahepatic glutathione synthesis and related gene expression. Glutathione is a key antioxidant, and changes in its production may indicate shifts in the liver's oxidative stress response.

Figure 7

Effects of MSM, CBD-rich cannabis extract, and their combination on intrahepatic glutathione synthesis and related gene expression. Glutathione is a key antioxidant, and changes in its production may indicate shifts in the liver's oxidative stress response.

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Figure 6

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Source Paper

Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration.

International journal of molecular sciences (2020)

PMID: 33096940

DOI: 10.3390/ijms21207808

Cite This Figure

![Figure 6: Intrahepatic expression of cytochrome P450 enzymes in response to MSM, CBD-rich cannabis extract (CRCE), or their combination. Alterations in CYP450 expression are critical for assessing drug-supplement interaction potential and metabolic safety.](https://pdfs.citedhealth.com/figures/33096940/99.png)

> Source: Kristy R Kutanzi et al. "Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Ext." *International journal of molecular sciences*, 2020. PMID: [33096940](https://pubmed.ncbi.nlm.nih.gov/33096940/)
<figure>
  <img src="https://pdfs.citedhealth.com/figures/33096940/99.png" alt="Intrahepatic expression of cytochrome P450 enzymes in response to MSM, CBD-rich cannabis extract (CRCE), or their combination. Alterations in CYP450 expression are critical for assessing drug-supplement interaction potential and metabolic safety." />
  <figcaption>Figure 6. Intrahepatic expression of cytochrome P450 enzymes in response to MSM, CBD-rich cannabis extract (CRCE), or their combination. Alterations in CYP450 expression are critical for assessing drug-supplement interaction potential and metabolic safety.<br>  Source: Kristy R Kutanzi et al. "Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Ext." <em>International journal of molecular sciences</em>, 2020. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/33096940/">33096940</a></figcaption>
</figure>

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