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Figure 5. Effects of MSM, CRCE, or MSM/CRCE on intrahepatic synthesis of glutathione and the expression of genes associated with the synthesis of glutathione. (A) Intrahepatic concentrations of total glutathione; (B–D) mRNA levels of (B) Gclm, (C) Gpx1, an
Figure 7. Figure 5. Effects of MSM, CRCE, or MSM/CRCE on intrahepatic synthesis of glutathione and the expression of genes associated with the synthesis of glutathione. (A) Intrahepatic concentrations of total glutathione; (B–D) mRNA levels of (B) Gclm, (C) Gpx1, and (D) Gsr in the mouse livers 24 h after the last dose of CRCE. Gene expression was measured using quantitative real-time (qRT) PCR. Data was analyzed by two-way ANOVA with Bonferroni post-test and are presented as mean ± SD fold change from vehicle (n = 6–8), with * as p < 0.05.

Beschreibung

Effects of MSM, CBD-rich cannabis extract, and their combination on intrahepatic glutathione synthesis and related gene expression. Glutathione is a key antioxidant, and changes in its production may indicate shifts in the liver's oxidative stress response.

More Figures from This Paper

Extended molecular analysis data examining the effects of CBD-rich cannabis extract and MSM on cellular detoxification pathways. The results contribute to understanding the safety implications of co-supplementation.

Figure 5

Extended molecular analysis data examining the effects of CBD-rich cannabis extract and MSM on cellular detoxification pathways. The results contribute to understanding the safety implications of co-supplementation.

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Intrahepatic expression of cytochrome P450 enzymes in response to MSM, CBD-rich cannabis extract (CRCE), or their combination. Alterations in CYP450 expression are critical for assessing drug-supplement interaction potential and metabolic safety.

Figure 6

Intrahepatic expression of cytochrome P450 enzymes in response to MSM, CBD-rich cannabis extract (CRCE), or their combination. Alterations in CYP450 expression are critical for assessing drug-supplement interaction potential and metabolic safety.

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Figure 7

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Source Paper

Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration.

International journal of molecular sciences (2020)

PMID: 33096940

DOI: 10.3390/ijms21207808

Cite This Figure

![Figure 7: Effects of MSM, CBD-rich cannabis extract, and their combination on intrahepatic glutathione synthesis and related gene expression. Glutathione is a key antioxidant, and changes in its production may indicate shifts in the liver's oxidative stress response.](https://pdfs.citedhealth.com/figures/33096940/108.png)

> Source: Kristy R Kutanzi et al. "Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Ext." *International journal of molecular sciences*, 2020. PMID: [33096940](https://pubmed.ncbi.nlm.nih.gov/33096940/)
<figure>
  <img src="https://pdfs.citedhealth.com/figures/33096940/108.png" alt="Effects of MSM, CBD-rich cannabis extract, and their combination on intrahepatic glutathione synthesis and related gene expression. Glutathione is a key antioxidant, and changes in its production may indicate shifts in the liver's oxidative stress response." />
  <figcaption>Figure 7. Effects of MSM, CBD-rich cannabis extract, and their combination on intrahepatic glutathione synthesis and related gene expression. Glutathione is a key antioxidant, and changes in its production may indicate shifts in the liver's oxidative stress response.<br>  Source: Kristy R Kutanzi et al. "Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Ext." <em>International journal of molecular sciences</em>, 2020. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/33096940/">33096940</a></figcaption>
</figure>

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