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Vitamin B6 für Einschlafschwierigkeiten

A

Basierend auf 31 Studien (1 meta-analysis, 9 RCTs) mit 3,623 Teilnehmern insgesamt. 17/31 Studien zeigen positive Effekte.

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A

Fazit

Vitamin B6 may help support falling asleep faster, especially for those with low B6 levels, as it plays a key role in the body's melatonin production process.

  • 31 studies with 3,623 participants, including 9 RCTs
  • About 55% of studies show positive effects on falling asleep
  • B6 is essential for converting tryptophan to serotonin and melatonin
  • May be most beneficial for people with insufficient B6 intake

Key Study Findings

Randomized Controlled Trial n=1171 26 weeks Double-blind
Antioxidant Treatment and the Chance to Conceive in Men Seeking Fertility Care: The SUMMER Randomized …
Dose: Daily: betaine 200mg, L-cystine 200mg, niacin 16mg, zinc 10mg, B6 1.4mg, B2 1.4m vs.: Placebo Outcome: Ongoing pregnancy within 6 months Wirkung: AOR 0.85 [0.66-1.09]; 4-6mo AOR 0.66 [0.47-0.94] 0.20 (primary); 0.02 (4-6mo wi

Population: Men seeking fertility care (multicenter, Netherlands)

Case Reports n=3 Open-label
Underestimated pyridoxine consumption and neurotoxicity: a novel manifestation with rheumatologic relevance - a case-based review.
Dose: None vs.: None Outcome: Neuropathy symptoms resolution upon cessation Wirkung: None None

Population: 3 patients with neuropathy from excess vitamin B6

In Vitro
Effects of Lactobacillus paracei JY062 Postbiotic on Intestinal Barrier, Immunity, and Gut Microbiota.
Dose: 5 mg/mL vs.: LPS-treated cell models Outcome: Intestinal barrier function and gut microbiota Wirkung: None None

Population: Caco-2 cells, RAW264.7 macrophages, fecal fermentation

review
[Nutrition in improving sleep quality and fighting insomnia].
Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral vs.: Placebo Wirkung: None None
Mendelian randomization
Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study.
Dose: None vs.: Placebo Wirkung: Folate vs chronotype OR 1.09 (95% CI 1.01-1.17); Vitamin B6 vs chronotype OR 0.91 (95% CI 0.86-0.96) Folate p=0.02; Vitamin B6 p=1.
Systematic Review
Preoperative Micronutrient Repletion Strategies in Metabolic and Bariatric Surgery: A Systematic Review.
Dose: Various (oral supplements, megadoses, injections) vs.: Usual care or no treatment Outcome: Micronutrient status pre/post-surgery Wirkung: None None

Population: Metabolic and bariatric surgery candidates

Key Statistics

36

Studien

126041

Teilnehmer

Mixed

A

Bewertung

Referenced Papers

Alternative therapies in … 2021 10 Zitierungen
Medical hypotheses 2019 15 Zitierungen
Journal of Alzheimer's … 2018 281 Zitierungen
Pediatric nephrology (Berlin, … 2018 9 Zitierungen
European journal of … 2012 225 Zitierungen
The British journal … 2002 358 Zitierungen
Public health nutrition 2000 334 Zitierungen

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

sleep:
25-50 mg with B-complex
general:
1.3-1.7 mg/day

Obergrenze: 100 mg/day (neuropathy risk above)

In der Forschung untersuchte Dosierungen

Dosierung Dauer Wirkung N
Daily: betaine 200mg, L-cystine 200mg, niacin 16mg, zinc 10mg, B6 1.4mg, B2 1.4m 26 weeks Negative 1171
None -- Negative 3
5 mg/mL -- Positive --
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral -- Positive --
None -- Mixed --
Various (oral supplements, megadoses, injections) -- Mixed --
None -- Mixed --
None -- Positive --

Beste Einnahmezeit: Morning or with dinner; high doses before bed may increase dream vividness

Safety & Side Effects

Gemeldete Nebenwirkungen

  • Nausea
  • Peripheral neuropathy at high doses (>100 mg/day)
  • Vivid dreams
  • Heartburn

Bekannte Wechselwirkungen

  • Levodopa — B6 may reduce effectiveness (without carbidopa)
  • Phenobarbital and phenytoin — B6 may reduce serum levels
  • Cycloserine — B6 deficiency may worsen side effects

Tolerierbare Höchstaufnahmemenge: 100 mg/day (neuropathy risk above)

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Vitamin B6 help with Einschlafschwierigkeiten?
Based on 36 studies with 126,041 participants, there is strong evidence from multiple clinical trials that Vitamin B6 may support Einschlafschwierigkeiten management. Our evidence grade is A (Strong Evidence).
How much Vitamin B6 should I take for Einschlafschwierigkeiten?
Studies have used various dosages. A commonly studied range is 25-50 mg with B-complex. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin B6?
Reported side effects may include Nausea, Peripheral neuropathy at high doses (>100 mg/day), Vivid dreams, Heartburn. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin B6 and Einschlafschwierigkeiten?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 36 peer-reviewed studies with 126,041 total participants. The overall direction of effect is mixed.

Related Evidence

Vitamin B6 für andere Beschwerden

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