Acute Effects of Oral Cannabinoids on Sleep and High-Density EEG in Insomnia: A Pilot Randomised Controlled Trial.

Journal of sleep research 2026 2 citations

Efficacy and associated neurotransmitters of digital cognitive behavior therapy for atopic dermatitis: A comparative effectiveness research.

Asian Pacific journal of allergy and immunology 2025 6 citations

Effects of a cannabidiol/terpene formulation on sleep in individuals with insomnia: a double-blind, placebo-controlled, randomized, crossover study.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2025 6 citations

Short-term oral zinc supplementation enhances Natural Killer cell functionality and decreases circulating Innate Lymphoid Cell counts and frequencies in healthy young adults.

Journal of translational medicine 2025 6 citations

Antioxidant Treatment and the Chance to Conceive in Men Seeking Fertility Care: The SUMMER Randomized Clinical Trial.

JAMA network open 2025 4 citations

The effect of nightly use of 150 mg cannabidiol on daytime neurocognitive performance in primary insomnia: a randomized controlled pilot trial.

Psychopharmacology 2025 3 citations

Effectiveness of Full Spectrum Cannabis Extracts in the Treatment of Chronic Pain: An Open Label Study.

Journal of pain & palliative care pharmacotherapy 2025 1 citation

Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial.

Brain and behavior 2025 1 citation

Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, placebo-controlled trial.

PloS one 2025 1 citation

Tissue zinc restoration alleviates the levodopa-induced dyskinesia via impeding ERK phosphorylation.

European journal of nutrition 2025

Evaluating the effect of cannabidiol on sleep quality in patients with multiple sclerosis using 15 aggregated N-of-1 trials: A study protocol.

Contemporary clinical trials 2025

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.

Animals : an open access journal from MDPI 2025

A prospective randomized controlled trial of antioxidants in human IVF and embryo culture media.

Human reproduction (Oxford, England) 2025

Effectiveness of a Cannabinoids Supplement on Sleep and Mood in Adults With Subthreshold Insomnia: A Randomized Double-Blind Placebo-Controlled Crossover Pilot Trial.

Health science reports 2025

D-Ribose-L-Cysteine protects against sodium arsenite-induced hepato-nephrotoxicity in rats.

Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria 2025

Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind, and placebo-controlled clinical trial.

Trends in psychiatry and psychotherapy 2024 36 citations

Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.

Advances in therapy 2024 24 citations

Cannabidiol for moderate-severe insomnia: a randomized controlled pilot trial of 150 mg of nightly dosing.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2024 17 citations

Effect of probiotic administration during pregnancy on the functional diversity of the gut microbiota in healthy pregnant women.

Microbiology spectrum 2024 9 citations

Medicinal Cannabis (MedCan 3): a randomised, multicentre, double-blind, placebo-controlled trial to assess THC/CBD (1:20) to relieve symptom burden in patients with cancer-a study protocol for a randomised controlled trial.

Trials 2024 8 citations

Evaluating possible 'next day' impairment in insomnia patients administered an oral medicinal cannabis product by night: a pilot randomized controlled trial.

Psychopharmacology 2024 7 citations

Rethinking clinical trials in restless legs syndrome: A roadmap.

Sleep medicine reviews 2024 6 citations

A randomized double-blind pilot study to evaluate the efficacy, safety, and tolerability of intravenous iron versus oral iron for the treatment of restless legs syndrome in patients with iron deficiency anemia.

American journal of hematology 2024 6 citations

Detection of Δ9-tetrahydrocannabinol (THC) in oral fluid using two point-of-collection testing devices following oral administration of a THC and cannabidiol containing oil.

Drug testing and analysis 2024 4 citations

Efficacy and Tolerability of a Food Supplement Based on Zea mays L., Gymnema sylvestre (Retz.) R.br.ex Sm, Zinc and Chromium for the Maintenance of Normal Carbohydrate Metabolism: A Monocentric, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Nutrients 2024 3 citations

Bacterial cellulose matrix and acellular dermal matrix seeded with fibroblasts grown in platelet-rich plasma supplemented medium, compared to free gingival grafts: a randomized animal study.

Journal of periodontal & implant science 2024

Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study.

Journal of sleep research 2023 40 citations

Cannabis-opioid interaction in the treatment of fibromyalgia pain: an open-label, proof of concept study with randomization between treatment groups: cannabis, oxycodone or cannabis/oxycodone combination-the SPIRAL study.

Trials 2023 12 citations

Understanding feeling "high" and its role in medical cannabis patient outcomes.

Frontiers in pharmacology 2023 11 citations

Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes.

Redox biology 2023 5 citations

Targeting neuroendocrine abnormalities in Parkinson's disease with exercise.

Frontiers in neuroscience 2023 5 citations

Roxadustat treatment for anemia in peritoneal dialysis patients: A randomized controlled trial.

Journal of the Formosan Medical Association = Taiwan yi zhi 2022 55 citations

Topical Cannabidiol (CBD) After Total Knee Arthroplasty Does Not Decrease Pain or Opioid Use: A Prospective Randomized Double-Blinded Placebo-Controlled Trial.

The Journal of arthroplasty 2022 35 citations

[Therapeutic approaches for sleep and rhythms disorders in children with ASD].

L'Encephale 2022 21 citations

Bacillus amyloliquefaciens CU33 fermented feather meal-soybean meal product improves the intestinal morphology to promote the growth performance of broilers.

Poultry science 2022 20 citations

Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.

BMC complementary medicine and therapies 2022 16 citations

Sini powder with paroxetine ameliorates major depressive disorder by modulating circadian rhythm: A randomized, double-blind, placebo-controlled trial.

Journal of pineal research 2022 13 citations

Effects of dietary methyl sulfonyl methane and selenium on laying performance, egg quality, gut health indicators, and antioxidant capacity of laying hens.

Animal bioscience 2022 9 citations

Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice and the pharmacokinetics of its active ingredients under conditions of glycerol fatty acid ester as emulsifiers.

Journal of ethnopharmacology 2022 8 citations

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with men who binge drink alcohol.

Alcoholism, clinical and experimental research 2022 4 citations

Mood, sleep and pain comorbidity outcomes in cannabis dependent patients: Findings from a nabiximols versus placebo randomised controlled trial.

Drug and alcohol dependence 2022 4 citations

Acute oral toxicity, antinociceptive and antimicrobial activities of kava dried extracts and synthetic kavain.

Natural product research 2022 3 citations

Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway.

NPJ Parkinson's disease 2022

Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study.

Journal of ethnopharmacology 2021 58 citations

A pilot study on essential oil aroma stimulation for enhancing slow-wave EEG in sleeping brain.

Scientific reports 2021 46 citations

Lavender essential oil on postmenopausal women with insomnia: Double-blind randomized trial.

Complementary therapies in medicine 2021 41 citations

Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study.

The journal of obstetrics and gynaecology research 2021 38 citations

Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.

Clinical and translational medicine 2021 36 citations

An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: a randomised, double-blind, placebo-controlled, multi-dose study.

Sleep medicine 2021 32 citations

Optimizing Multivitamin Supplementation for Sleeve Gastrectomy Patients.

Obesity surgery 2021 13 citations

Efficacy of inhaled Lavandula angustifolia Mill. Essential oil on sleep quality, quality of life and metabolic control in patients with diabetes mellitus type II and insomnia.

Journal of ethnopharmacology 2020 73 citations

Efficacy of melatonin for sleep disturbance in middle-aged primary insomnia: a double-blind, randomised clinical trial.

Sleep medicine 2020 41 citations

Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. A pilot study.

Reumatismo 2020 21 citations

Use of nutritional supplements based on melatonin, tryptophan and vitamin B6 (Melamil Tripto®) in children with primary chronic headache, with or without sleep disorders: a pilot study.

Minerva pediatrica 2020 11 citations

Resetting the late timing of 'night owls' has a positive impact on mental health and performance.

Sleep medicine 2019 102 citations

Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study.

Cureus 2019 101 citations

L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.

Journal of psychiatric research 2019 46 citations

The safety, tolerability, and effectiveness of PTL-101, an oral cannabidiol formulation, in pediatric intractable epilepsy: A phase II, open-label, single-center study.

Epilepsy & behavior : E&B 2019 38 citations

Beneficial effects of Silexan on sleep are mediated by its anxiolytic effect.

Journal of psychiatric research 2019 32 citations

Selenium Supplementation and Prostate Health in a New Zealand Cohort.

Nutrients 2019 15 citations

Treatment of restless legs syndrome: Evidence-based review and implications for clinical practice (Revised 2017)§.

Movement disorders : official journal of the Movement Disorder Society 2018 145 citations

Long-Term Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children with Autism Spectrum Disorder.

Journal of child and adolescent psychopharmacology 2018 133 citations

Effects of Pharmacologic and Nonpharmacologic Interventions on Insomnia Symptoms and Self-reported Sleep Quality in Women With Hot Flashes: A Pooled Analysis of Individual Participant Data From Four MsFLASH Trials.

Sleep 2018 85 citations

Prospective Clinical Trial of Ixazomib, Dexamethasone, and Rituximab as Primary Therapy in Waldenström Macroglobulinemia.

Clinical cancer research : an official journal of the American Association for Cancer Research 2018 65 citations

Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms.

American journal of therapeutics 2018 61 citations

Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial.

Journal of medicinal food 2018 37 citations

A phase 1/2 study of rigosertib in patients with myelodysplastic syndromes (MDS) and MDS progressed to acute myeloid leukemia.

Leukemia research 2018 35 citations

A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock.

Chronobiology international 2018 13 citations

Meal Timing Regulates the Human Circadian System.

Current biology : CB 2017 455 citations

Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder.

Journal of the American Academy of Child and Adolescent Psychiatry 2017 245 citations

The effects of chamomile extract on sleep quality among elderly people: A clinical trial.

Complementary therapies in medicine 2017 65 citations

The Effect of Aromatherapy on Insomnia and Other Common Symptoms Among Patients With Acute Leukemia.

Oncology nursing forum 2017 58 citations

Evaluation of effectiveness and safety of a herbal compound in primary insomnia symptoms and sleep disturbances not related to medical or psychiatric causes.

Nature and science of sleep 2017 12 citations

Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial.

International journal of immunopathology and pharmacology 2016 43 citations

Effects of valerian on subjective sedation, field sobriety testing and driving simulator performance.

Accident; analysis and prevention 2016 17 citations

Tasimelteon for non-24-hour sleep-wake disorder in totally blind people (SET and RESET): two multicentre, randomised, double-masked, placebo-controlled phase 3 trials.

Lancet (London, England) 2015 112 citations

Efficacy of orally administered Silexan in patients with anxiety-related restlessness and disturbed sleep--A randomized, placebo-controlled trial.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2015 84 citations

Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety.

Journal of ethnopharmacology 2015 68 citations

A mindfulness-based stress management program and treatment with omega-3 fatty acids to maintain a healthy mental state in hospital nurses (Happy Nurse Project): study protocol for a randomized controlled trial.

Trials 2015 31 citations

Vitamin D and L-cysteine levels correlate positively with GSH and negatively with insulin resistance levels in the blood of type 2 diabetic patients.

European journal of clinical nutrition 2014 77 citations

Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers.

Nutrition journal 2014 76 citations

Efficacy of omega-3 for vasomotor symptoms treatment: a randomized controlled trial.

Menopause (New York, N.Y.) 2014 69 citations

Response to intravenous iron in patients with iron deficiency anemia (IDA) and restless leg syndrome (Willis-Ekbom disease).

Sleep medicine 2014 58 citations

The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial.

Journal of the American Geriatrics Society 2011 138 citations

Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study.

BMC complementary and alternative medicine 2011 112 citations

A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomnia.

Sleep medicine 2009 89 citations

Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial.

Nutrition journal 2008 51 citations

Self-reported efficacy and tolerability of ramelteon 8 mg in older adults experiencing severe sleep-onset difficulty.

The American journal of geriatric pharmacotherapy 2007 41 citations

Randomized Controlled Trials