Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
Marcos Lacasa,
Jose Alegre-Martin,
Ramon Sanmartin Sentañes,
Luisa Varela-Sende,
Joanna Jurek
et al.
RCT
Nutrients
2023
9 цитирований
PubMed
DOI
CC-BY
PDF
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Study Design
- Тип исследования
- RCT
- Размер выборки
- 65
- Длительность
- 36 weeks
- Вмешательство
- Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Contro 4 capsules daily, each containing: beta-glucan 250 mg + vitamin D3 3.75 µg + vitamin B6 1.05 mg + zi
- Препарат сравнения
- Placebo
- Направление эффекта
- Positive
- Риск систематической ошибки
- Low
Abstract
This research aimed to examine the potential alleviative effects of beta-glucan administration on fatigue, unrefreshing sleep, anxiety/depression symptoms and health-related quality of life in ME/CFS. A 36-week unicenter, randomized, double-blind, placebo-controlled trial was conducted in 65 ME/CFS patients, who were randomly allocated to one of two arms to receive four capsules each one of 250 mg beta-glucan, 3.75 µg vitamin D3, 1.05 mg vitamin B6, and 7.5 mg zinc (n = 35), or matching placebo including only microcrystalline cellulose as an excipient (n = 30) once daily. The findings showed that the beta-glucan supplementation significantly improved cognitive fatigue (assessed with FIS-40 scores) after the 36-week treatment compared to the baseline (p = 0.0338). Taken together, this study presents the novel finding that yeast-derived beta-glucan may alleviate cognitive fatigue symptoms in ME/CFS. Thus, it offers valuable scientific insights into the potential use of yeast beta-glucan as a nutritional supplement and/or functional food to prevent or reduce cognitive dysfunction in patients with ME/CFS. Further interventions are warranted to validate these findings and also to delve deeper into the possible immunometabolic pathomechanisms of beta-glucans in ME/CFS.
Full Text
Figures
Tables
Table 5
| SF-36 Domains | Baseline | 36-Weeks | |
|---|---|---|---|
| Active arm (n = 29) | |||
| Physical functioning | 38.45 ± 20.49 | 40.17 ± 22.50 | 0.8178 |
| Physical role functioning | 6.03 ± 16.66 | 10.34 ± 20.61 | 0.2020 |
| Bodily pain | 15.93 ± 15.58 | 20.90 ± 18.68 | 0.1468 |
| General health perception | 22.76 ± 14.18 | 21.90 ± 13.19 | 0.5683 |
| Vitality | 12.24 ± 13.53 | 16.55 ± 15.93 | 0.0526 |
| Social role functioning | 32.33 ± 26.63 | 36.64 ± 25.65 | 0.3344 |
| Emotional role functioning | 34.48 ± 46.70 | 28.74 ± 43.39 | 0.1695 |
| Mental health status | 38.21 ± 21.18 | 42.07 ± 22.69 | 0.1393 |
| Placebo (n = 22) | |||
| Physical functioning | 39.32 ± 21.17 | 38.18 ± 20.21 | 0.9243 |
| Physical role functioning | 1.14 ± 5.33 | 4.55 ± 16.61 | 0.3287 |
| Bodily pain | 20.14 ± 19.22 | 23.73 ± 15.33 | 0.1089 |
| General health perception | 25.32 ± 14.49 | 27.36 ± 17.57 | 0.3225 |
| Vitality | 17.27 ± 16.24 | 15.23 ± 12.77 | 0.5847 |
| Social role functioning | 30.68 ± 20.68 | 42.05 ± 22.34 | 0.0131 * |
| Emotional role functioning | 33.33 ± 44.84 | 37.88 ± 45.19 | 0.4797 |
| Mental health status | 38.73 ± 23.11 | 44.73 ± 20.01 | 0.1918 |
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