Vitamin B6
vitaminAlso known as: Pyridoxine, Pyridoxal-5-phosphate, P5P
About
Vitamin B6 is a coenzyme critical for the synthesis of both serotonin and GABA, two neurotransmitters central to sleep regulation. Research suggests that adequate B6 status supports healthy melatonin production, though supplementation may be most beneficial for those who are deficient.
How It Works
Coenzyme for AADC (converts 5-HTP to serotonin) and glutamate decarboxylase (produces GABA from glutamate).
Side Effects
- Nausea
- Peripheral neuropathy at high doses (>100 mg/day)
- Vivid dreams
- Heartburn
Drug & Supplement Interactions
- Levodopa — B6 may reduce effectiveness (without carbidopa)
- Phenobarbital and phenytoin — B6 may reduce serum levels
- Cycloserine — B6 deficiency may worsen side effects
Always inform your healthcare provider about all supplements you take.
Related Ingredients
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.