Iron
mineralAlso known as: Ferrous sulfate, Iron bisglycinate
About
Iron is essential for dopamine synthesis and oxygen transport throughout the body. Iron deficiency is the primary cause of restless leg syndrome (RLS), a condition that significantly disrupts sleep. Research suggests that supplementing iron when ferritin is low may help reduce RLS symptoms.
How It Works
Required for dopamine synthesis (tyrosine hydroxylase cofactor); iron deficiency is the primary cause of RLS.
Evidence For Conditions
| Condition | Grade | Studies | Participants | |
|---|---|---|---|---|
| Restless Leg Syndrome | A Strong | 51 | 20577 | View → |
Side Effects
- Constipation
- Nausea
- Stomach pain
- Dark stools
- Iron overload risk (hemochromatosis)
Drug & Supplement Interactions
- Antacids and PPIs — reduce iron absorption
- Levothyroxine — iron reduces thyroid medication absorption
- Antibiotics (tetracyclines, fluoroquinolones) — mutual absorption reduction
- Calcium supplements — take separately by 2 hours
Always inform your healthcare provider about all supplements you take.
Related Ingredients
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.