Apigenin
flavonoidAlso known as: 4',5,7-trihydroxyflavone
About
Apigenin is a flavonoid abundant in chamomile and other plants, recognized for its calming properties. Research suggests it may support sleep by binding to GABA-A benzodiazepine receptors and inhibiting CD38, an enzyme involved in NAD+ metabolism and circadian regulation.
How It Works
Potent GABA-A benzodiazepine-site agonist; inhibits CD38 enzyme, increasing NAD+ for circadian regulation.
Evidence For Conditions
| Condition | Grade | Studies | Participants | |
|---|---|---|---|---|
| Sleep Onset Difficulty | D Preliminary | 0 | -- | View → |
Side Effects
- Drowsiness
- Muscle relaxation
- Sedation at high doses
Drug & Supplement Interactions
- Sedatives and benzodiazepines — additive GABAergic effects
- CYP2C9 substrates — apigenin may inhibit this enzyme
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