5-HTP
amino_acidAlso known as: 5-Hydroxytryptophan, Oxitriptan
About
5-HTP is the direct precursor to serotonin, which is subsequently converted to melatonin in the pineal gland. Research suggests it may support sleep by increasing serotonin and melatonin production, though caution is warranted due to potential serotonin-related interactions.
How It Works
Direct serotonin precursor that crosses BBB; serotonin is converted to melatonin in the pineal gland.
Evidence For Conditions
| Condition | Grade | Studies | Participants | |
|---|---|---|---|---|
| Insomnia | B Moderate | 31 | 83 | View → |
| Sleep Onset Difficulty | D Preliminary | 7 | -- | View → |
Side Effects
- Nausea
- Diarrhea
- Heartburn
- Stomach pain
- Drowsiness
Drug & Supplement Interactions
- SSRIs/SNRIs — serious risk of serotonin syndrome
- MAOIs — dangerous serotonin accumulation
- Tramadol — increased serotonin syndrome risk
- Carbidopa — may cause scleroderma-like skin changes
Always inform your healthcare provider about all supplements you take.
Related Ingredients
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.