The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study.
M Touret,
N Sarda,
A Gharib,
M Geffard,
M Jouvet
Other
Experimental brain research
1991
20 citations
Study Design
- Study Type
- animal study
- Population
- Rats pretreated with parachlorophenylalanine (p-CPA), a serotonin synthesis inhibitor
- Intervention
- The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study. L-5-HTP (dose not specified); 5-HTP + benserazide (L-aromatic-acid-decarboxylase inhibitor)
- Comparator
- PCPA-pretreated rats without 5-HTP
- Primary Outcome
- restoration of sleep (reversal of PCPA-induced insomnia)
- Effect Direction
- Positive
- Risk of Bias
- Moderate
Abstract
In the rat, the insomnia which follows the administration of parachlorophenylalanine (p-CPA), a serotonin synthesis inhibitor, is transiently reversed either by intra-cisternal injection of L-5-HTP or by an associated injection of 5-HTP and an L-aromatic-acid-decarboxylase inhibitor (benserazide). Histochemical, immunohistochemical and chemical investigations showed that 5-HTP administration does not lead to a detectable increase in cerebral 5-HT. These findings suggest that the restoration of sleep after p-CPA treatment could be mediated by the central action of 5-HTP.
TL;DR
Findings suggest that the restoration of sleep after p-CPA treatment could be mediated by the central action of 5-HTP.