Description

Proposed mechanistic model summarizes how circadian disruption reduces BMAL1 levels, leading to decreased MUC4 transcription, impaired tear film stability, and dry eye disease development.

Figure 15

Diagram

Source Paper

Circadian disruption reduces MUC4 expression via the clock molecule BMAL1 during dry eye development.

Experimental & molecular medicine (2024)

PMID: 38956298

DOI: 10.1038/s12276-024-01269-0

Cite This Figure

![Figure 15: Proposed mechanistic model summarizes how circadian disruption reduces BMAL1 levels, leading to decreased MUC4 transcription, impaired tear film stability, and dry eye disease development.]()

> Source: Hao Zeng et al. "Circadian disruption reduces MUC4 expression via the clock molecule BMAL1 during." *Experimental & molecular medicine*, 2024. PMID: [38956298](https://pubmed.ncbi.nlm.nih.gov/38956298/)

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  <img src="" alt="Proposed mechanistic model summarizes how circadian disruption reduces BMAL1 levels, leading to decreased MUC4 transcription, impaired tear film stability, and dry eye disease development." />
  <figcaption>Figure 15. Proposed mechanistic model summarizes how circadian disruption reduces BMAL1 levels, leading to decreased MUC4 transcription, impaired tear film stability, and dry eye disease development.<br>  Source: Hao Zeng et al. "Circadian disruption reduces MUC4 expression via the clock molecule BMAL1 during." <em>Experimental & molecular medicine</em>, 2024. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38956298/">38956298</a></figcaption>
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