SleepCited

Vitamin D for Insomnia

A Strong

Based on 49 studies (2 meta-analyses, 1 RCT) with 680,771 total participants. Results are mixed across studies.

Key Statistics

49

Studies

680771

Participants

↔

Mixed

A Strong

Grade

Referenced Papers

Vitamin D and Sleep Disorders. Review
Advances in experimental … 2026
Nutritional Supplements for Healthy Aging: A Critical Analysis Review. Review
American journal of … 2025 6 citations
Vitamin D deficiency and its potential associations on the health status of older patients with chronic obstructive pulmonary disease in … Other
Clinical nutrition ESPEN 2025 1 citations
Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis. Systematic Review
Frontiers in neurology 2025 1 citations
Loneliness, insomnia symptoms, social jetlag, and vitamin D deficiency in relation to mental health problems in Japanese female university students: … Other
Journal of physiological … 2025 1 citations
The synergistic interaction of vitamin D deficiency and insomnia on dizziness-related handicap in patients with benign paroxysmal positional vertigo. Other
Frontiers in neurology 2025 1 citations
Genome wide association study of a Circadian Imbalance Index in 312,935 European ancestry UK Biobank participants identifies loci related to … Other
Research square 2025
Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study. Other
Brain and behavior 2025
Top studies of 2024 relevant to primary care: From the PEER team. Review
Canadian family physician … 2025
[Nutrition in improving sleep quality and fighting insomnia]. Review
Nutricion hospitalaria 2025
A History of Psycho-Neuro-Endocrine Immune Interactions in Rheumatic Diseases. Review
Neuroimmunomodulation 2024 2 citations
Diffuse Large B-Cell Lymphoma Presenting With Hypercalcemia. Case Report
Cureus 2024 2 citations
Clinical and genetic associations for night eating syndrome in a patient biobank. Other
Journal of eating … 2024 1 citations
Highly prevalent geriatric medications and their effect on β-amyloid fibril formation. Other
BMC neurology 2024 1 citations
Causal Relationship Between Micronutrient and Sleep Disorder: A Mendelian Randomization Study. Other
Nature and science … 2024 1 citations
[Advances in Mendelian randomization studies on autism spectrum disorder]. Review
Zhongguo dang dai … 2024
Depression and lifestyle: Focusing on nutrition, exercise, and their possible relevance to molecular mechanisms. Meta-Analysis
Psychiatry and clinical … 2023 67 citations
Sleep Disturbances in Generalized Anxiety Disorder: The Role of Calcium Homeostasis Imbalance. Other
International journal of … 2023 19 citations
Sleep Patterns Modify the Association between Vitamin D Status and Coronary Heart Disease: Results from NHANES 2005-2008. Other
The Journal of … 2023 9 citations
Complementary and Integrative Approaches to Sleep Disorders in Children. Review
Child and adolescent … 2023 5 citations
Integrative Approaches in the Treatment of Patients Affected by Lymphoma. Review
Current oncology reports 2023 5 citations
The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the United … Other
Frontiers in nutrition 2023 3 citations
The Prevalence of Restless Legs Syndrome Among Pregnant Women in Saudi Arabia. Other
Cureus 2023 3 citations
Early risk assessment and prediction model for osteoporosis based on traditional Chinese medicine syndromes. Other
Heliyon 2023 3 citations
Vitamin D deficiency promoting non-24 h sleep-wake disorder: a case report. Case Report
Frontiers in neurology 2023 3 citations
Top 20 Research Studies of 2022 for Primary Care Physicians. Other
American family physician 2023
Digital Addiction and Sleep. Review
International journal of … 2022 107 citations
The Role of Vitamin D in Sleep Disorders of Children and Adolescents: A Systematic Review. Systematic Review
International journal of … 2022 36 citations
Sleep status in multiple sclerosis: Role of vitamin D and body mass index. Other
Current journal of … 2022 11 citations
Behavioral sleep medicine-The need for harmonization of clinical best practice outcome measures in children and adolescents with intellectual or developmental … Review
Frontiers in psychiatry 2022 8 citations
The use of dietary supplements for mental health among the Saudi population: A cross-sectional survey. Other
Saudi pharmaceutical journal … 2022 4 citations
Vitamin D levels in primary care patients: correlations with clinical, seasonal, and quality-of-life parameters. Other
Family practice 2022 2 citations
Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. Other
Journal of the … 2021 22 citations
Nutraceuticals for Sleep Disorders. Review
Combinatorial chemistry & … 2021 16 citations
No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial. Other
Sleep medicine: X 2021 9 citations
High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls. Other
Basic and clinical … 2021 2 citations
Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship. Review
Journal of neural … 2020 194 citations
Quality of life of patients more than 1 year after surgery for thyroid cancer. Other
Hormones (Athens, Greece) 2020 20 citations
Efficacy of low-fat milk and yogurt fortified with encapsulated vitamin D3 on improvement in symptoms of insomnia and quality of … Other
Food science & … 2020 17 citations
Baseline Vitamin D Status, Sleep Patterns, and the Risk of Incident Type 2 Diabetes in Data From the UK Biobank … Other
Diabetes care 2020
Relationship Between Nutritional Status and Insomnia Severity in Older Adults. Other
Journal of the … 2019 58 citations
Pharmacotherapeutic management of sleep disorders in children with neurodevelopmental disorders. Review
Expert opinion on … 2019 49 citations
Relationship between 25-Hydroxyvitamin D, bone density, and Parkinson's disease symptoms. Other
Acta neurologica Scandinavica 2019 36 citations
Association between Vitamin D Status and Premenstrual Symptoms. Other
Journal of the … 2019 16 citations
Sleep and biological parameters in professional burnout: A psychophysiological characterization. Other
PloS one 2018 69 citations
Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2months. Other
Clinica chimica acta; … 2017 14 citations
Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … RCT
Minerva ginecologica 2011 19 citations
Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in advanced non-small-cell lung cancer patients with low performance status. Other
Cancer biotherapy & … 2006 29 citations
Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT
Minerva ginecologica 2006

Dosage & Usage

Commonly Used Dosages

general:
600-800 IU/day
deficiency:
1,000-5,000 IU/day

Upper limit: 4,000 IU/day

Dosages Studied in Research

Dosage Duration Effect N
None -- Positive --
None -- Mixed 312935
None -- Mixed --
None -- Neutral 138
None -- Mixed --
None -- Positive --
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral -- Positive --
None -- Mixed --

Best taken: Morning with a meal containing fat; avoid evening dosing

Safety & Side Effects

Reported Side Effects

  • ⚠ Hypercalcemia at high doses
  • ⚠ Nausea
  • ⚠ Constipation
  • ⚠ Kidney stones (rare, with excessive intake)

Known Interactions

  • ● Corticosteroids — reduce calcium absorption, affecting vitamin D metabolism
  • ● Weight-loss drugs (orlistat) — may reduce vitamin D absorption
  • ● Statins — vitamin D may affect statin metabolism

Tolerable upper intake: 4,000 IU/day

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Vitamin D help with Insomnia?
Based on 49 studies with 680,771 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Insomnia management. Our evidence grade is A (Strong).
How much Vitamin D should I take for Insomnia?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at high doses, Nausea, Constipation, Kidney stones (rare, with excessive intake). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Insomnia?
We rate the evidence as Grade A (Strong). This rating is based on 49 peer-reviewed studies with 680,771 total participants. The overall direction of effect is mixed.

Related Evidence

Vitamin D for other conditions

Sleep Maintenance Insomnia D Preliminary

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.