Sleep disturbances in a case of brain-stem lesions; pharmacological study.
تصميم الدراسة
- نوع الدراسة
- Case report
- حجم العينة
- 1
- المجتمع المدروس
- Single case of severe insomnia following brain-stem lesions, studied with polygraphic sleep controls while comparing effects of delta-sleep-inducing peptide (DSIP), 5-HTP, L-DOPA, and clonazepam.
- التدخل
- Sleep disturbances in a case of brain-stem lesions; pharmacological study. None
- المقارن
- 5-HTP + benzerazide; L-DOPA + benzerazide (Modopar); clonazepam (Rivotril)
- النتيجة الأولية
- Sleep duration and quality (REM/NREM ratio, paradoxical sleep latency) following DSIP injection
- اتجاه التأثير
- Positive
- خطر التحيز
- High
الملخص
A pharmacological study was carried out of a case of severe insomnia following brain-stem lesions; several polygraphic controls were used. Initially total duration of sleep was brief (less than 4 h) with a high REM/NREM ratio and a short paradoxical sleep (PS) latency. In addition, periodic breathing and tremor were observed. Slow injection of delta-sleep-inducing peptide (DSIP) improved sleep both quantitatively and qualitatively, although PS latency remained short. These effects were reversible. The effects of 5-HTP + benzerazide, of L-DOPA + benzerazide (Modopar) and of clonazepam (Rivotril) were compared.
باختصار
Slow injection of delta-sleep-inducing peptide (DSIP) improved sleep both quantitatively and qualitatively, although PS latency remained short, although these effects were reversible.