[Implication of hypothalamic structures in indolaminergic mechanisms of paradoxical sleep].
M Sallanon,
F Petitjean,
C Buda,
M Janin,
M Jouvet
Other
Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie
1983
2 citações
PubMed
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Study Design
- Tipo de Estudo
- Animal study
- Intervenção
- [Implication of hypothalamic structures in indolaminergic mechanisms of paradoxical sleep]. 1-20 micrograms L-5-HTP (brainstem); 2-7 micrograms L-5-HTP (ventrolateral hypothalamus)
- Comparador
- Placebo
- Direção do Efeito
- Positive
- Risco de Viés
- Moderate
Abstract
Intratissue injection of 1 to 20 micrograms of L-5 HTP in numerous areas of the cat brainstem failed to reverse P-chlorophenylalanine induced insomnia. On the other hand, injection of 2 to 7 micrograms of L-5 HTP in the ventrolateral hypothalamus induced both slow wave sleep and paradoxical sleep after 36 and 76 min.
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