Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology.
Richard P Allen
Review
Sleep medicine clinics
2015
158 件の引用
研究デザイン
- 研究タイプ
- Review
- 対象集団
- Patients with restless leg syndrome/Willis-Ekbom disease
- 介入
- Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology.
- 比較対照
- None
- 主要アウトカム
- Pathophysiology of restless leg syndrome/Willis-Ekbom disease
- 効果の方向
- Neutral
- バイアスリスク
- Unclear
抄録
Restless leg syndrome/Willis-Ekbom disease has brain iron deficiency that produces excessive dopamine and known genetic risks, some of which contribute to the brain iron deficiency. Dopamine treatments work temporarily but may eventually produce further postsynaptic down-regulation and worse restless leg syndrome. This article includes sections focused on pathophysiologic findings from each of these areas: genetics, cortical-spinal excitability, and iron and dopamine.
要約
Part of this article includes sections focused on pathophysiologic findings from each of these areas: genetics, cortical-spinal excitability, and iron and dopamine.