Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases.
Disegno dello studio
- Tipo di studio
- Review
- Popolazione
- In vitro and in vivo models of neurodegenerative diseases; review of Ashwagandha effects
- Intervento
- Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases.
- Comparatore
- None
- Esito primario
- Effects and mechanisms of Ashwagandha (Withania somnifera) on neurodegenerative diseases (Alzheimer's disease, spinal cord injury) in in vitro and in vivo models
- Direzione dell'effetto
- Positive
- Rischio di bias
- Unclear
Abstract
Neurodegenerative diseases commonly induce irreversible destruction of central nervous system (CNS) neuronal networks, resulting in permanent functional impairments. Effective medications against neurodegenerative diseases are currently lacking. Ashwagandha (roots of Withania somnifera Dunal) is used in traditional Indian medicine (Ayurveda) for general debility, consumption, nervous exhaustion, insomnia, and loss of memory. In this review, we summarize various effects and mechanisms of Ashwagandha extracts and related compounds on in vitro and in vivo models of neurodegenerative diseases such as Alzheimer's disease and spinal cord injury.
TL;DR
Various effects and mechanisms of Ashwagandha extracts and related compounds on in vitro and in vivo models of neurodegenerative diseases such as Alzheimer's disease and spinal cord injury are summarized.