Efficacy and side effects of chloral hydrate and tryptophan as sleeping aids in psychogeriatric patients.
M Linnoila,
M Viukari,
A Numminen,
J Auvinen
Other
International pharmacopsychiatry
1980
PubMed
DOI
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'sleepcited.com';
const params = 'pmid\u003D7002832';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
Abstract
The effects of placebo, L-tryptophan 3 g, and chloral hydrate 500 mg on sleep were studied in 19 nonpsychotic, mildly demented, geriatric inpatients. Only chloral hydrate was more effective in inducing and maintaining sleep than placebo. Neither chloral hydrate not L-tryptophan had any significant side effects, but withdrawal of chloral hydrate was associated with insomnia.
Used In Evidence Reviews
Similar Papers
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017
Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.
1097 citations
Open Access
Sleep medicine reviews · 2011
A systematic review of insomnia and complementary medicine.
317 citations
Alternative medicine review : a journal of clinical therapeutic · 1998
5-Hydroxytryptophan: a clinically-effective serotonin precursor.
216 citations
Annual review of nutrition · 2021
Sleep and Diet: Mounting Evidence of a Cyclical Relationship.
149 citations
Open Access
Psychosomatic medicine · 1999
Dietary supplements and natural products as psychotherapeutic agents.
136 citations
Drugs & aging · 2018
Insomnia in Elderly Patients: Recommendations for Pharmacological Management.
131 citations