Nonhematological benefits of iron.
Plan d'étude
- Type d'étude
- Review
- Population
- Patients with chronic kidney disease and iron deficiency; general population with iron deficiency
- Intervention
- Nonhematological benefits of iron. None
- Comparateur
- None
- Critère de jugement principal
- Non-hematological benefits of iron supplementation including immune function, physical performance, thermoregulation, cognition, restless leg syndrome
- Direction de l'effet
- Positive
- Risque de biais
- Unclear
Résumé
Iron deficiency anemia is common in people with chronic kidney disease (CKD) and its importance in supporting erythropoiesis is unquestioned especially in those patients treated with erythropoietin. Clinical symptomatology such as fatigability, cold intolerance, failure to concentrate and poor effort intolerance is often attributed to anemia or uremia. That iron deficiency, per se, can cause these symptoms is poorly recognized. Clinical and animal studies that support the benefits of iron supplementation, independent of increasing hemoglobin, such as those on immune function, physical performance, thermoregulation, cognition, and restless leg syndrome and aluminum absorption is the subject of this narrative review.
En bref
Clinical and animal studies that support the benefits of iron supplementation, independent of increasing hemoglobin, such as those on immune function, physical performance, thermoregulation, cognition, and restless leg syndrome and aluminum absorption are the subject of this narrative review.